S. Bolotin, S. Osman, S. Hughes, A. Ariyarajah, A. Tricco, Sumaiya Khan, Lennon Li, Caitlin Johnson, L. Friedman, Nazish Gul, Rachel Jardine, Maryrose Faulkner, S. Hahné, J. Heffernan, A. Dabbagh, P. Rota, A. Severini, M. Jit, D. Durrheim, W. Orenstein, W. Moss, S. Funk, N. Turner, W. Schluter, J. Jawad, N. Crowcroft
{"title":"在消除环境中,麻疹抗体在接种疫苗后减弱,但在感染后不会减弱——一项系统综述和荟萃分析。","authors":"S. Bolotin, S. Osman, S. Hughes, A. Ariyarajah, A. Tricco, Sumaiya Khan, Lennon Li, Caitlin Johnson, L. Friedman, Nazish Gul, Rachel Jardine, Maryrose Faulkner, S. Hahné, J. Heffernan, A. Dabbagh, P. Rota, A. Severini, M. Jit, D. Durrheim, W. Orenstein, W. Moss, S. Funk, N. Turner, W. Schluter, J. Jawad, N. Crowcroft","doi":"10.1093/infdis/jiac039","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nWe conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings.\n\n\nMETHODS\nAfter screening 16,822 citations, we identified nine articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria.\n\n\nRESULTS\nUsing linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received two doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% CI -212.4, -31.1) per year since vaccination over one to five years, 53.7 mIU/mL (95% CI -95.3, -12.2) five to ten years, 33.2 mIU/mL (95% CI -62.6, -3.9) ten to 15 years, and 24.1 mIU/mL (95% CI -51.5,3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after one dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after one or two doses of MCV, or after infection.\n\n\nCONCLUSIONS\nMeasles antibody waning in vaccinated populations should be considered in planning for measles elimination.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"62 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"In Elimination Settings, Measles Antibodies Wane Following Vaccination but Not Following Infection - A Systematic Review and Meta-Analysis.\",\"authors\":\"S. Bolotin, S. Osman, S. Hughes, A. Ariyarajah, A. Tricco, Sumaiya Khan, Lennon Li, Caitlin Johnson, L. Friedman, Nazish Gul, Rachel Jardine, Maryrose Faulkner, S. Hahné, J. Heffernan, A. Dabbagh, P. Rota, A. Severini, M. Jit, D. Durrheim, W. Orenstein, W. Moss, S. Funk, N. Turner, W. Schluter, J. Jawad, N. Crowcroft\",\"doi\":\"10.1093/infdis/jiac039\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND\\nWe conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings.\\n\\n\\nMETHODS\\nAfter screening 16,822 citations, we identified nine articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria.\\n\\n\\nRESULTS\\nUsing linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received two doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% CI -212.4, -31.1) per year since vaccination over one to five years, 53.7 mIU/mL (95% CI -95.3, -12.2) five to ten years, 33.2 mIU/mL (95% CI -62.6, -3.9) ten to 15 years, and 24.1 mIU/mL (95% CI -51.5,3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after one dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after one or two doses of MCV, or after infection.\\n\\n\\nCONCLUSIONS\\nMeasles antibody waning in vaccinated populations should be considered in planning for measles elimination.\",\"PeriodicalId\":22572,\"journal\":{\"name\":\"The Indonesian Journal of Infectious Diseases\",\"volume\":\"62 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Indonesian Journal of Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/infdis/jiac039\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Indonesian Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/infdis/jiac039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
摘要
背景:我们进行了一项系统综述,以评估在麻疹消除环境中,以前感染或接种过麻疹疫苗的人群中麻疹体液免疫是否会减弱。方法在筛选16,822篇引用后,我们从暴露于野生型麻疹的人群中筛选出9篇文章,从接种疫苗的人群中筛选出16篇符合我们的纳入标准的文章。结果使用线性回归,我们发现接种两剂含麻疹疫苗(MCV)的个体的几何平均滴度(GMTs)在接种后1至5年内每年下降121.8 mIU/mL (95% CI -212.4, -31.1), 5至10年下降53.7 mIU/mL (95% CI -95.3, -12.2), 10至15年下降33.2 mIU/mL (95% CI -62.6, -3.9), 15至20年下降24.1 mIU/mL (95% CI -51.5,3.3)。在一剂MCV或感染后,GMT随时间的降低并不显著。在一剂或两剂MCV或感染后,随着时间的推移,血清阳性个体比例的下降并不显著。结论麻疹疫苗接种人群的麻疹抗体下降应在制定麻疹消灭计划时予以考虑。
In Elimination Settings, Measles Antibodies Wane Following Vaccination but Not Following Infection - A Systematic Review and Meta-Analysis.
BACKGROUND
We conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings.
METHODS
After screening 16,822 citations, we identified nine articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria.
RESULTS
Using linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received two doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% CI -212.4, -31.1) per year since vaccination over one to five years, 53.7 mIU/mL (95% CI -95.3, -12.2) five to ten years, 33.2 mIU/mL (95% CI -62.6, -3.9) ten to 15 years, and 24.1 mIU/mL (95% CI -51.5,3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after one dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after one or two doses of MCV, or after infection.
CONCLUSIONS
Measles antibody waning in vaccinated populations should be considered in planning for measles elimination.