离子凝胶法制备甲氧胺酸微球及评价

Journal of Pharmaceutical and Scientific Innovation Pub Date : 2022-10-26 DOI:10.7897/2277-4572.115236

Subhashitha S, Ashitha Meharooz, Haseena ., Nasheel Shereen, Ravi Kumar

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引用次数: 0

摘要

本研究的目的是利用离子凝胶技术制备甲胺酸微球。通过改变聚合物的比例，共制备了三种配方。对制备的微球进行药物包封效率、溶胀指数和体外药物释放度评价。在3种制剂中，F3制剂即(1:2)药聚合物比为最佳制剂，产率高、包封效率高、溶胀指数高、体外释药效果好。

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FORMULATION AND EVALUATION OF MEFENAMIC ACID MICROSPHERES BY IONIC GELATION TECHNIQUE

The aim of the present investigation is to prepare mefenamic acid microspheres by ionic gelation technique. A total of three formulations were prepared by altering the polymer ratio. The obtained microspheres were evaluated for drug entrapment efficiency, swelling index, and in vitro drug release. Out of three formulation F3 formulation i.e., (1:2) drug: polymer ratio was found to best formulation with high product yield, Drug entrapment efficiency, Swelling index, and in vitro drug release.

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Journal of Pharmaceutical and Scientific Innovation

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