新生儿败血症:过去、现在和未来;一篇综述文章

S. Tripathi, G. Malik
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引用次数: 72

摘要

脓毒症是新生儿死亡的最常见原因。根据2002-2003年全国新生儿围产期数据库(NNPD),印度新生儿败血症的发病率为每1000例活产30例。这一比例在校内出生的婴儿中为3%,在校外入学的婴儿中为39.7%。新生儿败血症的早期表现是模糊和不明确的。诊断新生儿败血症的新方法包括心电图心率分析或肤色比色分析。虽然血培养是诊断败血症的金标准,但培养报告只有在48-72小时后才能获得。在这个多药耐药的时代,必须避免不必要地使用抗生素来治疗未感染的婴儿。因此,区分感染和未感染婴儿的快速诊断测试,特别是在新生儿早期,包括白细胞介素-6 (IL-6)、中性粒细胞CD64指数、降钙素原和有核红细胞计数,有可能对新生儿护理产生重大影响。本综述的目的是明确败血症的诊断标准、治疗指南和最新诊断试验的总结。关键词:脓毒症;校内的;市外的;多药耐药性
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neonatal Sepsis: past, present and future; a review article
Sepsis is the most common cause of neonatal mortality. As per National Neonatal Perinatal Database (NNPD) 2002-2003, the incidence of neonatal sepsis in India was 30 per 1000 live birth. It is 3% among intramural babies and 39.7% among extramural admissions. The early manifestations of neonatal sepsis are vague and ill-defined. Novel approaches in the diagnosis of neonatal sepsis include heart rate analysis on ECG or colorimetric analysis of skin color. Although blood culture is the gold standard for the diagnosis of sepsis, culture reports would be available only after 48-72 hours. In this era of multidrug resistance, it is mandatory to avoid unnecessary use of antibiotics to treat noninfected infants. Thus, rapid diagnostic test(s) that differentiate infected from non-infected infants, particularly in the early newborn period, that include Interleukien-6 (IL-6), neutrophil CD64 index, procalcitonin and nucleated RBC count, have the potential to make a significant impact on neonatal care. The aim of this review is to specify the diagnostic criteria, treatment guidelines and a summary of the newer diagnostic tests of sepsis. KEY WORDS: Sepsis; Intramural; Extramural; Multidrug resistance
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