C. Daher, R. Taleb, M. Mroueh, Bilal Nehmeh, Hachem Araji, Rawan H. Chakas, A. Daccache, Kamar H. Eid, Maria K. El Khoury, Pamela F. El Hayek, Hala T. Faddoul, Elio Junior Feghali, Ahmad Ghanem, Tony P. Haydar, Abir R. Jammoul, Sula H. Nasra, Nouhad Saade, Donna G. Tahan, J. Daher, Esther Tannoury, W. Shebaby
{"title":"月桂叶提取物对大鼠高脂肪饮食诱导的2型糖尿病有保护作用","authors":"C. Daher, R. Taleb, M. Mroueh, Bilal Nehmeh, Hachem Araji, Rawan H. Chakas, A. Daccache, Kamar H. Eid, Maria K. El Khoury, Pamela F. El Hayek, Hala T. Faddoul, Elio Junior Feghali, Ahmad Ghanem, Tony P. Haydar, Abir R. Jammoul, Sula H. Nasra, Nouhad Saade, Donna G. Tahan, J. Daher, Esther Tannoury, W. Shebaby","doi":"10.5897/JPP2021.0609","DOIUrl":null,"url":null,"abstract":"Laurus nobilis, commonly known as bay, is used in folk medicine as a remedy for many ailments. The present study investigates the protective effect of L. nobilis leaves extract against high fat diet-induced type 2 diabetes in rats. Animals were divided into group 1 (control), groups 2, 3, and 4 (bay leaves aqueous (AQ) extracts; 50, 100, and 250 mg/kg of body weight, respectively), and groups 5, 6, and 7 (bay leaves methanol/acetone (MeAc) extract; 50, 100, and 250 mg/kg of body weight, respectively). Animals were fed an isocaloric high fat diet for four weeks. The intake of bay leaves extracts was associated with a significant decreases in serum levels of glucose (AQ, 100 and 250 mg/kg; MeAc, 50, 100, and 250 mg/kg) and serum triglyceride (AQ, 250 mg/kg; MeAc, 100, and 250 mg/kg) as well as lower abdominal fat (all AQ and MeAc groups) and body weight gain (MeAc groups only). In conclusion, L. nobilis leaves extract intake provides a protective remedy against high fat diet-induced type 2 diabetes. \n \n Key words: Laurus nobilis, type 2 diabetes, bay leaves, high fat diet.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"6 1","pages":"82-90"},"PeriodicalIF":0.0000,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Laurus nobilis leaves extract protects against high fat diet-induced type 2 Diabetes in rats\",\"authors\":\"C. Daher, R. Taleb, M. Mroueh, Bilal Nehmeh, Hachem Araji, Rawan H. Chakas, A. Daccache, Kamar H. Eid, Maria K. El Khoury, Pamela F. El Hayek, Hala T. Faddoul, Elio Junior Feghali, Ahmad Ghanem, Tony P. Haydar, Abir R. Jammoul, Sula H. Nasra, Nouhad Saade, Donna G. Tahan, J. Daher, Esther Tannoury, W. Shebaby\",\"doi\":\"10.5897/JPP2021.0609\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Laurus nobilis, commonly known as bay, is used in folk medicine as a remedy for many ailments. The present study investigates the protective effect of L. nobilis leaves extract against high fat diet-induced type 2 diabetes in rats. Animals were divided into group 1 (control), groups 2, 3, and 4 (bay leaves aqueous (AQ) extracts; 50, 100, and 250 mg/kg of body weight, respectively), and groups 5, 6, and 7 (bay leaves methanol/acetone (MeAc) extract; 50, 100, and 250 mg/kg of body weight, respectively). Animals were fed an isocaloric high fat diet for four weeks. The intake of bay leaves extracts was associated with a significant decreases in serum levels of glucose (AQ, 100 and 250 mg/kg; MeAc, 50, 100, and 250 mg/kg) and serum triglyceride (AQ, 250 mg/kg; MeAc, 100, and 250 mg/kg) as well as lower abdominal fat (all AQ and MeAc groups) and body weight gain (MeAc groups only). In conclusion, L. nobilis leaves extract intake provides a protective remedy against high fat diet-induced type 2 diabetes. \\n \\n Key words: Laurus nobilis, type 2 diabetes, bay leaves, high fat diet.\",\"PeriodicalId\":16801,\"journal\":{\"name\":\"Journal of Pharmacognosy and Phytotherapy\",\"volume\":\"6 1\",\"pages\":\"82-90\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmacognosy and Phytotherapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5897/JPP2021.0609\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacognosy and Phytotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5897/JPP2021.0609","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Laurus nobilis leaves extract protects against high fat diet-induced type 2 Diabetes in rats
Laurus nobilis, commonly known as bay, is used in folk medicine as a remedy for many ailments. The present study investigates the protective effect of L. nobilis leaves extract against high fat diet-induced type 2 diabetes in rats. Animals were divided into group 1 (control), groups 2, 3, and 4 (bay leaves aqueous (AQ) extracts; 50, 100, and 250 mg/kg of body weight, respectively), and groups 5, 6, and 7 (bay leaves methanol/acetone (MeAc) extract; 50, 100, and 250 mg/kg of body weight, respectively). Animals were fed an isocaloric high fat diet for four weeks. The intake of bay leaves extracts was associated with a significant decreases in serum levels of glucose (AQ, 100 and 250 mg/kg; MeAc, 50, 100, and 250 mg/kg) and serum triglyceride (AQ, 250 mg/kg; MeAc, 100, and 250 mg/kg) as well as lower abdominal fat (all AQ and MeAc groups) and body weight gain (MeAc groups only). In conclusion, L. nobilis leaves extract intake provides a protective remedy against high fat diet-induced type 2 diabetes.
Key words: Laurus nobilis, type 2 diabetes, bay leaves, high fat diet.
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