Security of Microfluidic Biochip

With the advancement of system miniaturization and automation, Lab-on-a-Chip (LoC) technology has revolutionized traditional experimental procedures. Microfluidic Biochip (MFB) is an emerging branch of LoC with wide medical applications such as DNA sequencing, drug delivery, and point of care diagnostics. Due to the critical usage of MFBs, their security is of great importance. In this article, we exploit the vulnerabilities of two types of MFBs: Flow-based Microfluidic Biochip (FMFB) and Digital Microfluidic Biochip (DMFB). We propose a systematic framework for applying Reverse Engineering (RE) attacks and Hardware Trojan (HT) attacks on MFBs as well as for practical countermeasures against the proposed attacks. We evaluate the attacks and defense on various benchmarks where experimental results prove the effectiveness of our methods. Security metrics are defined to quantify the vulnerability of MFBs. The overhead and performance of the proposed attacks as well as countermeasures are also discussed.