The Relation of Omentin-1 Levels and Some Trace Elements as a Potential Markers for Diagnosis of Prediabetic Obese Patients

Abstract The obesity is one of the most common physiological disorders, also it is linked with a variety of circumstances like hypertension, dyslipidemia, T2DM, non-alcoholic fatty liver disease, and cardiovascular diseases. The aim of this study was to check the changes and compare serum omentin-1, lipid profile (TC, TG, VLDL-C, LDL-C, and HDL-C), trace elements (Mg, Zn, Cu, Fe) and insulin resistance between the prediabetic obese patients, healthy obese, and control subjects and assess the correlation between omentin-1, lipid profile, trace elements (Mg, Zn, Cu, Fe) levels and insulin resistance in prediabetic obese patients. Correlation analysis between omentin-1 levels with the biochemical parameters in the prediabetic obese patients with WC, body mass index, FBG, Insulin, HOMA-IR, HbA1c, TG, TC, LDL-C, VLDL-C, and copper was found to be negative; while significant positive correlation of omentin-1 with HDL-C, Mg, Zn, and Fe was noticed. Omentin-1 serum concentration level decrease and insulin resistance increased in prediabetic obese patients compared to healthy obese and control individuals. Omentin-1 inversely associated with obesity and insulin resistance, therefore can be used as a biomarker for obesity related metabolic disorders.