短暂性脑缺血发作的工作记忆障碍：将 N-back 作为检测的灵敏度测量方法。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-01 Epub Date: 2021-12-15 DOI:10.1017/BrImp.2021.25

Laura J Smith, Polly Gregory, Philip Clatworthy, Lucy Gallop, George Stothart

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引用次数: 0

摘要

背景：短暂性脑缺血发作（TIA）可导致大脑结构和功能的持久性改变，从而造成认知障碍。认知筛查工具可能缺乏检测认知障碍的灵敏度，尤其是执行功能，而执行功能往往是血管性认知障碍中最早受到影响的领域。目的：在这项初步研究中，我们将工作记忆（WMem）任务作为衡量 TIA 认知障碍的灵敏指标：因短暂性神经症状转诊至 TIA 诊所的患者在横断面设计中完成了一般认知筛查工具（蒙特利尔认知评估；MoCA）和工作记忆任务（2-N-back）：TIA患者（12人）在N-back任务中的WMem表现明显低于症状重叠的模拟临床症状患者（16人）。在MoCA上没有观察到组间差异：评估WMem可以灵敏地测量TIA后的认知功能障碍，对TIA服务中的认知筛查具有重要意义，可将患者分流以获得进一步的神经心理学支持，或用于预防血管性痴呆的干预措施。

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Working Memory Impairment in Transient Ischaemic Attack: N-back as a Sensitive Measure for Detection.

Background: Transient ischaemic attack (TIA) can lead to lasting changes in brain structure and function resulting in cognitive impairment. Cognitive screening tools may lack sensitivity for detecting cognitive impairments, particularly executive function, which tends to be the earliest affected domain in vascular cognitive impairment.

Aim: In this preliminary study, we examine a working memory (WMem) task as a sensitive measure of cognitive impairment in TIA.

Method: Patients referred to a TIA clinic for transient neurological symptoms completed a general cognitive screening tool (Montreal Cognitive Assessment; MoCA), and a WMem task (2-N-back) in a cross-sectional design.

Results: TIA patients (n = 12) showed significantly reduced WMem performance on the N-back compared to patients diagnosed with mimic clinical conditions with overlapping symptoms (n = 16). No group differences were observed on the MoCA.

Conclusions: Assessing WMem may provide a sensitive measure of cognitive impairment after TIA, with implications for cognitive screening in TIA services to triage patients for further neuropsychological support, or for interventions to prevent vascular dementia.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.