C. Boutin, Y. Roche, R. Jaffiol, J. Millot, C. Millot, J. Plain, R. Déturche, P. Jeannesson, M. Manfait, P. Royer
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Effect of different agents onto multidrug resistant cells revealed by fluorescence correlation spectroscopy
Fluorescence correlation spectroscopy (FCS) has been used to analyze the plasma membrane fluidity and heterogene- ity of multidrug resistant cells. At the single cell level, the effects of different membrane agents present in the extra-cellular medium have been explored. Firstly, we reveal a modification of plasma membrane heterogeneities according to the addition of a fluidity modulator, benzyl alcohol. On the other hand, revertants such as verapamil and cyclosporin-A appear to act more specifically on the slow diffusion sites, such as lipids microdomains.
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