Ritambhara Pandey, Devesh Rai, Muhammad Waqas Tahir, Abdul Wahab, Dhrubajyoti Bandyopadhyay, Emil Lesho, Maryrose Laguio-Vila, Emilio Fentanes, Raseen Tariq, Srihari S Naidu, Wilbert S Aronow
{"title":"按病情严重程度划分的 COVID-19 成年患者合并症和症状的流行率:系统性综述。","authors":"Ritambhara Pandey, Devesh Rai, Muhammad Waqas Tahir, Abdul Wahab, Dhrubajyoti Bandyopadhyay, Emil Lesho, Maryrose Laguio-Vila, Emilio Fentanes, Raseen Tariq, Srihari S Naidu, Wilbert S Aronow","doi":"10.5114/amsad.2022.115008","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>We performed a systematic review of comorbidities and symptoms of adult patients with coronavirus disease 2019 (COVID-19) to evaluate comorbidities, symptoms, and severity.</p><p><strong>Material and methods: </strong>We searched databases and extracted comorbidities and symptoms from the included studies. We stratified the similar signs and symptoms in groups and on the basis of severity and compared them with stratified analysis. Individual case reports and case series with < 5 patients were excluded.</p><p><strong>Results: </strong>A total of 163 studies with 43,187 patients were included. Mean age was 54.6 years. There were significantly fewer women in the study (43.9% vs. 56.1%, <i>p</i> < 0.0001). Prevalent cardiovascular comorbidities were hypertension (31.9%), obesity (27.9%), hyperlipidemia (26.4%), smoking (18.9%), diabetes mellitus (17.2%), atherosclerotic disease (9.2%) and arrhythmia (5.0%). The most frequently reported constitutional symptoms of COVID-19 were fever (73.9%), fatigue (33.4%), malaise (29.9%), myalgia and/or arthralgia (19.2%), generalized weakness (19.0%), and chills (11.3%). For the cardiovascular system, chest pain and/or tightness were most often reported (19.6%), followed by palpitations (5.2%). Hypertension and diabetes were common in severe disease. Obesity and congestive heart failure were not observed in any non-severe cases. Severe cases compared to non-severe cases more frequently had fever (87.8% vs. 58.5%, <i>p</i> < 0.001), shortness of breath (47.4% vs. 20.6%, <i>p</i> < 0.001), cough (66.8% vs. 62.9%, <i>p</i> < 0.001), sputum production (35.4% vs. 26.5%, <i>p</i> < 0.001) and rhinorrhea (32.2% vs. 7.3%, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Hypertension, diabetes, and atherosclerotic diseases are common comorbidities across the world, with obesity as the second most common in the US and more common in men.</p>","PeriodicalId":55507,"journal":{"name":"Applicable Analysis","volume":"18 1","pages":"e5-e23"},"PeriodicalIF":1.1000,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081912/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevalence of comorbidities and symptoms stratified by severity of illness amongst adult patients with COVID-19: a systematic review.\",\"authors\":\"Ritambhara Pandey, Devesh Rai, Muhammad Waqas Tahir, Abdul Wahab, Dhrubajyoti Bandyopadhyay, Emil Lesho, Maryrose Laguio-Vila, Emilio Fentanes, Raseen Tariq, Srihari S Naidu, Wilbert S Aronow\",\"doi\":\"10.5114/amsad.2022.115008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>We performed a systematic review of comorbidities and symptoms of adult patients with coronavirus disease 2019 (COVID-19) to evaluate comorbidities, symptoms, and severity.</p><p><strong>Material and methods: </strong>We searched databases and extracted comorbidities and symptoms from the included studies. We stratified the similar signs and symptoms in groups and on the basis of severity and compared them with stratified analysis. Individual case reports and case series with < 5 patients were excluded.</p><p><strong>Results: </strong>A total of 163 studies with 43,187 patients were included. Mean age was 54.6 years. There were significantly fewer women in the study (43.9% vs. 56.1%, <i>p</i> < 0.0001). Prevalent cardiovascular comorbidities were hypertension (31.9%), obesity (27.9%), hyperlipidemia (26.4%), smoking (18.9%), diabetes mellitus (17.2%), atherosclerotic disease (9.2%) and arrhythmia (5.0%). The most frequently reported constitutional symptoms of COVID-19 were fever (73.9%), fatigue (33.4%), malaise (29.9%), myalgia and/or arthralgia (19.2%), generalized weakness (19.0%), and chills (11.3%). For the cardiovascular system, chest pain and/or tightness were most often reported (19.6%), followed by palpitations (5.2%). Hypertension and diabetes were common in severe disease. Obesity and congestive heart failure were not observed in any non-severe cases. Severe cases compared to non-severe cases more frequently had fever (87.8% vs. 58.5%, <i>p</i> < 0.001), shortness of breath (47.4% vs. 20.6%, <i>p</i> < 0.001), cough (66.8% vs. 62.9%, <i>p</i> < 0.001), sputum production (35.4% vs. 26.5%, <i>p</i> < 0.001) and rhinorrhea (32.2% vs. 7.3%, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Hypertension, diabetes, and atherosclerotic diseases are common comorbidities across the world, with obesity as the second most common in the US and more common in men.</p>\",\"PeriodicalId\":55507,\"journal\":{\"name\":\"Applicable Analysis\",\"volume\":\"18 1\",\"pages\":\"e5-e23\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2022-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081912/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applicable Analysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/amsad.2022.115008\",\"RegionNum\":4,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MATHEMATICS, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applicable Analysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/amsad.2022.115008","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MATHEMATICS, APPLIED","Score":null,"Total":0}
Prevalence of comorbidities and symptoms stratified by severity of illness amongst adult patients with COVID-19: a systematic review.
Introduction: We performed a systematic review of comorbidities and symptoms of adult patients with coronavirus disease 2019 (COVID-19) to evaluate comorbidities, symptoms, and severity.
Material and methods: We searched databases and extracted comorbidities and symptoms from the included studies. We stratified the similar signs and symptoms in groups and on the basis of severity and compared them with stratified analysis. Individual case reports and case series with < 5 patients were excluded.
Results: A total of 163 studies with 43,187 patients were included. Mean age was 54.6 years. There were significantly fewer women in the study (43.9% vs. 56.1%, p < 0.0001). Prevalent cardiovascular comorbidities were hypertension (31.9%), obesity (27.9%), hyperlipidemia (26.4%), smoking (18.9%), diabetes mellitus (17.2%), atherosclerotic disease (9.2%) and arrhythmia (5.0%). The most frequently reported constitutional symptoms of COVID-19 were fever (73.9%), fatigue (33.4%), malaise (29.9%), myalgia and/or arthralgia (19.2%), generalized weakness (19.0%), and chills (11.3%). For the cardiovascular system, chest pain and/or tightness were most often reported (19.6%), followed by palpitations (5.2%). Hypertension and diabetes were common in severe disease. Obesity and congestive heart failure were not observed in any non-severe cases. Severe cases compared to non-severe cases more frequently had fever (87.8% vs. 58.5%, p < 0.001), shortness of breath (47.4% vs. 20.6%, p < 0.001), cough (66.8% vs. 62.9%, p < 0.001), sputum production (35.4% vs. 26.5%, p < 0.001) and rhinorrhea (32.2% vs. 7.3%, p < 0.001).
Conclusions: Hypertension, diabetes, and atherosclerotic diseases are common comorbidities across the world, with obesity as the second most common in the US and more common in men.
期刊介绍:
Applicable Analysis is concerned primarily with analysis that has application to scientific and engineering problems. Papers should indicate clearly an application of the mathematics involved. On the other hand, papers that are primarily concerned with modeling rather than analysis are outside the scope of the journal
General areas of analysis that are welcomed contain the areas of differential equations, with emphasis on PDEs, and integral equations, nonlinear analysis, applied functional analysis, theoretical numerical analysis and approximation theory. Areas of application, for instance, include the use of homogenization theory for electromagnetic phenomena, acoustic vibrations and other problems with multiple space and time scales, inverse problems for medical imaging and geophysics, variational methods for moving boundary problems, convex analysis for theoretical mechanics and analytical methods for spatial bio-mathematical models.