草原蝰蛇毒液的二聚体崩解素

Доклады Академии наук Pub Date : 2019-10-20 DOI:10.31857/s0869-56524885567-570

E. Kryukova, A. S. Potapenko, T. Andreeva, I. Ivanov, V. V. Ryabinin, R. Ziganshin, V. Starkov, N. Ayvazyan, V. Tsetlin, Y. Utkin

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引用次数: 0

摘要

用液相色谱法从草原蝰蛇毒液中分离得到4个二聚体崩解素。崩解素阻止MCF7细胞与纤维连接蛋白的粘附，这表明它们与V1型整合素受体相互作用。根据质谱数据，崩解素的摩尔质量约为14 kDa。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dimeric disintegrins from the Vipera ursinii steppe viper venom

Four dimeric disintegrins were isolated from the venom of the steppe viper V. ursinii using liquid chromatography. Disintegrins prevented adhesion of MCF7 cells to fibronectin, which indicates their interaction with integrin receptors of the V1 type. According to mass spectrometry data, the molar masses of disintegrins are about 14 kDa.

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Доклады Академии наук

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