S. Merzouk, Michael V. Lee, N. Jaffrezic‐Renault, A. Errachid, N. Zine, J. Bausells, C. Viňas, F. Teixidor
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引用次数: 0
摘要
研制了异烟肼(INH)传感膜敏场效应晶体管(MEMFET)器件。优化后的INH膜由7% (w/w)离子对[H3-INH][Co(C2B9H11)2]3、30% (w/w)聚合物(聚氯乙烯)(PVC)和63% (w/w)增塑剂o-硝基苯乙基醚(NPOE)溶于四氢呋喃(THF)溶液的复合混合物组成。评估了电位反应。该器件在3×10-6 M ~ 1×10-1 M的浓度范围内具有良好的选择性和线性响应，斜率为55±0.2 mV/ 10年。inhmemfet适用于pH为9.5-5的水溶液，对其他抗结核药物(磺胺、利福平、乙胺丁醇和吡嗪甲酰胺)不敏感。
Development of a novel isoniazid-membrane-field-effect transistor
The Isoniazid (INH) sensing Membrane-Sensitive Field-Effect Transistor (MEMFET) device was developed. The optimized INH membrane was composed from a complex mixture of 7% (w/w) ion pair [H3-INH][Co(C2B9H11)2]3, 30% (w/w) polymer (polyvinyl chloride) (PVC), and 63% (w/w) of plasticizing agent o-nitrophenyloctyl ether (NPOE) which was dissolved in tetrahydrofuran (THF) solution. The potentiometric response was evaluated. The device exhibited excellent selectivity and a linear response over the concentration range from 3×10-6 M to 1×10-1 M with a slope of 55 ± 0.2 mV/decade. The INHMEMFETs are suitable for use with aqueous solutions of pH 9.5-5 and were found insensitive to the other antituberculosis (Sulfanilamide, Rifampicin, Ethambutol and pyrazinecarboxamide).
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