先天性黑素细胞痣

A. Marghoob
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摘要

©2015 John Wiley & Sons, Ltd版权所有。先天性黑素细胞痣(CMN)是一种先天性良性色素痣。总体发病率在1%到2%之间,对于成年期直径大于20厘米的痣,发病率约为1 / 20000。CMN可以表现为孤立的单一病变,也可以伴有不同数量的其他CMN。神经系统异常,特别是实质内黑化,是CMN最常见的并发症。最近,人们提出“先天性黑素细胞痣综合征”一词来描述CMN、皮肤外特征(如神经异常)和/或许多受影响儿童的典型相之间的关系。CMN患者恶性黑色素瘤的总发病率约为1%,出生时CMN bb0 - 40cm和卫星病变的患者风险增加。目前的手术技术尚未被证明能改变恶性肿瘤的风险,因此只能常规考虑改善美观。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Congenital melanocytic nevi
© 2015 John Wiley & Sons, Ltd. All rights reserved. Congenital melanocytic naevi (CMN) are benign pigmented naevi present at birth. The incidence ranges from 1 to 2% overall to approximately 1 in 20 000 for naevi projected to be greater than 20 cm in diameter in adulthood. CMN can present as isolated singular lesions or can be accompanied by a variable number of other CMN. Neurological abnormalities, in particular intraparenchymal melanosis, are the most common complication of CMN. Recently, the term congenital melanocytic naevus syndrome has been proposed to characterize the association between CMN, extracutaneous features such as neurological abnormalities and/or the typical facies of many affected children. The overall incidence of malignant melanoma in patients with CMN is approximately 1%, with an increased risk in patients with CMN > 40 cm and satellite lesions at birth. Surgery with current techniques has not been proven to alter the risk of malignancy and thus should only be routinely considered for aesthetic improvement.
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