Association of Brain-Derived Neurotrophic Factor (BDNF) Gene Snps G196A and C270T with Alzheimer’s Disease: A Meta-Analysis

The key pathological changes associated with AD brain tissue are the accumulation of intracellular neurofibrillary tangles (NFTs) and abnormally aggregated ‘reactive’ proteins like β amyloid (Aβ) plaques and tau [3]. Several elements, such as senile plaques, neurofibrillary tangles (NFTs), abnormally aggregated ‘reactive’ proteins like β amyloid (Aβ) and tau, brain inflammation and exposure to aluminum has already shown the development of AD [4]. Brain derived neurotrophic factor (BDNF) gene is supposed to be one of the important genes, playing a significant role in AD progression [5,6]. However, as a complex disorder, the neuropathological etiology of AD mentioned above are not due to the gene itself, but are also supposed to be associated with the combined interaction between genes and environmental factors.