Demystification – a solution for assessment of real-world effective-ness?

Nearly 100 years ago Archie Cochrane and Austin Bradford Hill proposed a three-dimensional assessment for evaluating clinical interventions: Can it Work? Does it work? Is it Worth it? [2, S1]. Table 1 proposes a strategy to answer these questions by description of three outcome dimensions that are assessed under two different conditions from three different perspectives. The strategy requires a different architecture of studies (form and function) and different tools.