Jing Wang, Xiuyun Liu, Yanni Chen, Bingjie Zhang, Yi Peng, Zhipeng Sun, Tao Yang
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MRI showed restricted diffusion and edema in the left frontoparietal cortex and subcortical white matter. The levels of 25-hydroxy-vitamin D (25-OH-VD) and bone gla-containing protein (BGP) in the observation group 180 days after treatment were higher, and the type I collagen n-terminal propeptide (PINP) and type I collagen cross-linked C-terminal telopeptide (<i>β</i>-CTX) were lower (<i>P</i> < 0.05). The visual analogue scale (VAS) score of the observation group at 180 days after treatment was lower, while the quality of life score was higher (<i>P</i> < 0.05). The median cell count in the observation group at 180 days after treatment was less, while the lymphocytes showed a higher level (<i>P</i> < 0.05). 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引用次数: 0
摘要
本研究主要探讨基于磁共振成像(MRI)的四物汤治疗脑卒中后偏瘫合并骨质疏松症的临床疗效和安全性。将120例脑卒中后偏瘫骨质疏松患者分为观察组(在对照组治疗方案的基础上加味四物汤治疗,60例)和对照组(神经内科常规药物+神经康复训练治疗的增肌手术,60例)。他们都接受了核磁共振扫描。结果显示,治疗后180 d,观察组腰椎、同侧股骨颈、同侧髌骨的骨密度(BMD)均高于对照组(P <;0.05)。MRI显示左侧额顶叶皮层和皮层下白质弥散受限和水肿。观察组患者治疗后180 D 25-羟基维生素D (25-OH-VD)和骨玻璃蛋白(BGP)水平较高,I型胶原n端前肽(PINP)和I型胶原交联c端末端肽(β-CTX)水平较低(P <;0.05)。观察组治疗后180 d视觉模拟评分(VAS)评分较低,生活质量评分较高(P <;0.05)。观察组在治疗后180天的中位细胞计数较少,而淋巴细胞水平较高(P <;0.05)。综上所述,四物汤能有效改善脑卒中后偏瘫骨质疏松患者的骨代谢,促进骨细胞的增殖和分化,改善患者的骨密度和生活质量。
Efficacy Evaluation of Modified Siwu Decoction to Treat Osteoporosis in Patients with Poststroke Hemiplegia by Using the Magnetic Resonance Imaging Features
This study was focused on the clinical efficacy and safety of magnetic resonance imaging (MRI)-based Siwu decoction for poststroke hemiplegia complicated with osteoporosis. 120 patients with poststroke hemiplegia and osteoporosis were divided into an observation group (modified Siwu decoction based on the treatment scheme of control group, 60 cases) and a control group (conventional drugs in neurology + neurology-based rehabilitation training treatment of muscle enhancement surgery, 60 cases). They all underwent MRI scans. The results showed that the bone mineral density (BMD) of lumbar spine, ipsilateral femoral neck, and ipsilateral patella in the observation group was higher than that in the control group 180 days after treatment (P < 0.05). MRI showed restricted diffusion and edema in the left frontoparietal cortex and subcortical white matter. The levels of 25-hydroxy-vitamin D (25-OH-VD) and bone gla-containing protein (BGP) in the observation group 180 days after treatment were higher, and the type I collagen n-terminal propeptide (PINP) and type I collagen cross-linked C-terminal telopeptide (β-CTX) were lower (P < 0.05). The visual analogue scale (VAS) score of the observation group at 180 days after treatment was lower, while the quality of life score was higher (P < 0.05). The median cell count in the observation group at 180 days after treatment was less, while the lymphocytes showed a higher level (P < 0.05). In conclusion, the Siwu decoction could effectively improve the bone metabolism of patients with poststroke hemiplegia and osteoporosis, promote the proliferation and differentiation of osteocytes, and improve the BMD and quality of life of patients.
期刊介绍:
Concepts in Magnetic Resonance Part A brings together clinicians, chemists, and physicists involved in the application of magnetic resonance techniques. The journal welcomes contributions predominantly from the fields of magnetic resonance imaging (MRI), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR), but also encourages submissions relating to less common magnetic resonance imaging and analytical methods.
Contributors come from academic, governmental, and clinical communities, to disseminate the latest important experimental results from medical, non-medical, and analytical magnetic resonance methods, as well as related computational and theoretical advances.
Subject areas include (but are by no means limited to):
-Fundamental advances in the understanding of magnetic resonance
-Experimental results from magnetic resonance imaging (including MRI and its specialized applications)
-Experimental results from magnetic resonance spectroscopy (including NMR, EPR, and their specialized applications)
-Computational and theoretical support and prediction for experimental results
-Focused reviews providing commentary and discussion on recent results and developments in topical areas of investigation
-Reviews of magnetic resonance approaches with a tutorial or educational approach