Martina Giovannella, Bjørn Andresen, Julie B Andersen, Sahla El-Mahdaoui, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Gorm Greisen, Turgut Durduran, Udo M Weigel, Ian Law
{"title":"弥散相关光谱与 15O 水 PET 在新生仔猪区域脑血流测量中的对比验证。","authors":"Martina Giovannella, Bjørn Andresen, Julie B Andersen, Sahla El-Mahdaoui, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Gorm Greisen, Turgut Durduran, Udo M Weigel, Ian Law","doi":"10.1177/0271678X19883751","DOIUrl":null,"url":null,"abstract":"<p><p>Diffuse correlation spectroscopy (DCS) can non-invasively and continuously asses regional cerebral blood flow (rCBF) at the cot-side by measuring a blood flow index (BFI) in non-traditional units of cm<sup>2</sup>/s. We have validated DCS against positron emission tomography using <sup>15</sup>O-labeled water (<sup>15</sup>O-water PET) in a piglet model allowing us to derive a conversion formula for BFI to rCBF in conventional units (ml/100g/min). Neonatal piglets were continuously monitored by the BabyLux device integrating DCS and time resolved near infrared spectroscopy (TRS) while acquiring <sup>15</sup>O-water PET scans at baseline, after injection of acetazolamide and during induced hypoxic episodes. BFI by DCS was highly correlated with rCBF (R = 0.94, <i>p</i> < 0.001) by PET. A scaling factor of 0.89 (limits of agreement for individual measurement: 0.56, 1.39)×10<sup>9</sup>× (ml/100g/min)/(cm<sup>2</sup>/s) was used to derive baseline rCBF from baseline BFI measurements of another group of piglets and of healthy newborn infants showing an agreement with expected values. These results pave the way towards non-invasive, cot-side absolute CBF measurements by DCS on neonates.</p>","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786848/pdf/","citationCount":"0","resultStr":"{\"title\":\"Validation of diffuse correlation spectroscopy against <sup>15</sup>O-water PET for regional cerebral blood flow measurement in neonatal piglets.\",\"authors\":\"Martina Giovannella, Bjørn Andresen, Julie B Andersen, Sahla El-Mahdaoui, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Gorm Greisen, Turgut Durduran, Udo M Weigel, Ian Law\",\"doi\":\"10.1177/0271678X19883751\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Diffuse correlation spectroscopy (DCS) can non-invasively and continuously asses regional cerebral blood flow (rCBF) at the cot-side by measuring a blood flow index (BFI) in non-traditional units of cm<sup>2</sup>/s. We have validated DCS against positron emission tomography using <sup>15</sup>O-labeled water (<sup>15</sup>O-water PET) in a piglet model allowing us to derive a conversion formula for BFI to rCBF in conventional units (ml/100g/min). Neonatal piglets were continuously monitored by the BabyLux device integrating DCS and time resolved near infrared spectroscopy (TRS) while acquiring <sup>15</sup>O-water PET scans at baseline, after injection of acetazolamide and during induced hypoxic episodes. BFI by DCS was highly correlated with rCBF (R = 0.94, <i>p</i> < 0.001) by PET. A scaling factor of 0.89 (limits of agreement for individual measurement: 0.56, 1.39)×10<sup>9</sup>× (ml/100g/min)/(cm<sup>2</sup>/s) was used to derive baseline rCBF from baseline BFI measurements of another group of piglets and of healthy newborn infants showing an agreement with expected values. These results pave the way towards non-invasive, cot-side absolute CBF measurements by DCS on neonates.</p>\",\"PeriodicalId\":15356,\"journal\":{\"name\":\"Journal of Cerebral Blood Flow & Metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786848/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cerebral Blood Flow & Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/0271678X19883751\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/10/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cerebral Blood Flow & Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/0271678X19883751","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/10/30 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Validation of diffuse correlation spectroscopy against 15O-water PET for regional cerebral blood flow measurement in neonatal piglets.
Diffuse correlation spectroscopy (DCS) can non-invasively and continuously asses regional cerebral blood flow (rCBF) at the cot-side by measuring a blood flow index (BFI) in non-traditional units of cm2/s. We have validated DCS against positron emission tomography using 15O-labeled water (15O-water PET) in a piglet model allowing us to derive a conversion formula for BFI to rCBF in conventional units (ml/100g/min). Neonatal piglets were continuously monitored by the BabyLux device integrating DCS and time resolved near infrared spectroscopy (TRS) while acquiring 15O-water PET scans at baseline, after injection of acetazolamide and during induced hypoxic episodes. BFI by DCS was highly correlated with rCBF (R = 0.94, p < 0.001) by PET. A scaling factor of 0.89 (limits of agreement for individual measurement: 0.56, 1.39)×109× (ml/100g/min)/(cm2/s) was used to derive baseline rCBF from baseline BFI measurements of another group of piglets and of healthy newborn infants showing an agreement with expected values. These results pave the way towards non-invasive, cot-side absolute CBF measurements by DCS on neonates.