羧酸为酰化剂，p2o5介导活化芳烃的Friedel-Crafts酰化反应

IF 0.5 4区化学 Q3 Pharmacology, Toxicology and Pharmaceutics

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2020-12-14 DOI:10.56042/ijcb.v59i12.29562

Rupali G. Kalshetti, Ram D. Mandle, Sanjay P. Kamble, A. Sudalai

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引用次数: 1

摘要

p2o5是一种高效的环境友好型催化剂，可在液相中以区域选择性的方式对活化的芳香底物进行酰化反应，生成芳香酮(45-93%)。芳香族羧酸和脂肪族羧酸均可作为酰化源。特别演示了在100克规模下以苯甲醚和乙酸生产4-甲氧基苯乙酮的过程。

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P2O5-mediated Friedel-Crafts acylation of activated arenes with carboxylic acid as acylating agent

P 2 O 5 has been found to be a highly efficient and environmental friendly catalyst for the liquid-phase acylation of activated aromatic substrates giving aromatic ketones (45-93%) in a regioselective manner. Both aromatic and aliphatic carboxylic acids can be employed as acylating source. The process is particularly demonstrated at 100 g scale in the case of anisole and acetic acid to produce 4-methoxyacetophenone.

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来源期刊

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry 化学-有机化学

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Indian Journal of Chemistry (Section B) is a leading monthly journal in Organic and Medicinal Chemistry started publishing from 1976. It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry. Apart from full length papers, notes and communications, the journal publishes short reviews on frontline areas under the column " advances in Contemporary Research".