外因和感染因素可引起流产

T. Gutor, N. Timchenko, O. Matsyura
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引用次数: 0

摘要

足月前不良生殖结果是一种与人口危机相关的多病理学。一些不良后果包括围产期和新生儿死亡率、两岁以下儿童的主要发病率和死亡率、精神运动和身体发育受到侵犯、五岁以下儿童的认知障碍和残疾。寻找解决这些问题的方法仍然是一个优先事项。这项研究涉及两组女性。实验组包括403名非自愿终止妊娠、早产或面临流产威胁的妇女;对照组为生理期妊娠妇女和足月妊娠产妇402例。这项研究需要采用系统的办法和方法,包括结构、逻辑、医学和统计分析。调查发现了20多种感染危险因素和70多种外阴来源因素。实验组和对照组最显著的感染病理分别为COVID-19(36.23±2.29%)和14.93±1.78%、疱疹1型(5.96±1.18%和1.0±0.50%)、弓形虫病(4.22±1.0%和1.0±0.50%)和衣原体感染(4.22±1.0% 0.50±0.35%)(P < 0.01)。试验组和对照组以自身免疫性甲状腺炎(8.68±1.40%和0.75±0.43%)、1型糖尿病(2.23±0.74%和0%)和变应性鼻炎/鼻窦炎(3.97±0.97%和0.50±0.35%)最为显著(P < 0.01)。获得的结果将用于开发人格化的风险导向模型,以预防早产。关键词:足月前不良生殖结局,外阴病理,感染病理,危险因素,风险导向模型
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extragenital and infectious factors may provoke miscarriage
Adverse reproductive outcome before term is a polyetiological pathology associated with demographic crisis. Some adverse outcomes include perinatal and neonatal infant mortality, major morbidity and mortality of children under two years, violation of psychomotor and physical development, cognitive disturbances and disability of children under age five. Finding ways to solve these issues remain a priority. The research involved two female groups. The experimental group included 403 women after the involuntary termination of pregnancy, premature birth or in case of threat of miscarriage; the control group included 402 women with physiological course of pregnancy and parturient with full-term pregnancy. The study required the application of systemic approaches and methods including structural, logical, medical and statistical analyses. The survey revealed more than 20 infectious risk factors and more than 70 factors of extragenital origin. The most significant infectious pathologies included COVID-19 (36.23 ± 2.29% and 14.93 ± 1.78%), herpes type 1 (5.96 ± 1.18% and 1.0 ± 0.50%), toxoplasmosis (4.22 ± 1.0% and 1.0 ± 0.50%) and chlamydial infection (4.22 ± 1.0% 0.50 ± 0.35%) in the experimental and control groups, respectively (P < 0.01). The most significant extragenital pathologies involved autoimmune thyroiditis (8.68 ± 1.40% and 0.75 ± 0.43%), type 1 diabetes mellitus (2.23 ± 0.74% and 0%) and allergic rhinitis/sinusitis (3.97 ± 0.97% and 0.50 ± 0.35%) in the experimental and control groups, respectively (P < 0.01). Obtained results will be used in the development of a personified risk-oriented model for the prevention of preterm pregnancy loss. Keywords: adverse reproductive outcomes before term, extragenital pathology, infectious pathology, risk factors, risk-oriented model
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