血脂异常:年轻人中风的一个原因

Vijay B. Gaikwad, Sharayu N Garud, Astha Ganeriwal
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引用次数: 0

摘要

中风是一种快速发展的临床症状,表现为持续24小时以上的局灶性或全局性脑功能紊乱。全世界高发病率和高死亡率的最重要原因之一是中风。脑血管疾病及其相关的梗死和出血既发生在老年人身上,也发生在年轻人身上。脂质谱的各种异常已被报道在年轻的中风患者。高胆固醇血症和高甘油三酯血症似乎都是动脉粥样硬化的重要危险因素。采用非概率方便抽样法在三级保健中心抽取50名受试者。在所有符合15-45岁年龄组纳入标准的患者中。32%的患者出现血脂异常[90% CI(22.31-43.53%)]。皮质静脉血栓9例(18%)[90% CI(10.78 ~ 28.50%)],均为女性。除一人外,其余人都处于产后状态。抗磷脂抗体综合征1例。分别有10% [90% CI(4.95 ~ 19.15%)]和4% [90% CI(1.33 ~ 11.39%)]的患者存在风湿性心脏病和系统性红斑狼疮。1例缺血性和出血性中风未确诊[90% CI(0.5-8.8%)]。血脂异常表现为低密度脂蛋白升高和高密度脂蛋白降低。血脂异常是年轻人中风最常见的病因。在评估这些患者时,诊断方面的挑战是可以预料的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dyslipidemia: A Cause of Stroke in Young Adults
Stroke is a “Rapidly developing clinical signs of focal or global disturbances of cerebral functions lasting for more than 24 hours”. 1 One of the most important causes of high morbidity and mortality all over the world is stroke. The diseases of cerebral blood vessels and their related infarcts and hemorrhages occur in the elderly as well as the young. The various abnormalities in lipid profile have been reported in young patients with stroke. Both hypercholesterolemia and hypertriglyceridemia appear to be important risk factors for atherosclerosis. A total of 50 subjects were selected by non-probability convenient sampling method at the tertiary care center. Out of all patients fulfilling the inclusion criteria of the age-group of 15–45 years. Dyslipidemia was seen in 32% [90% CI (22.31–43.53%)] of patients. Cortical venous thrombosis in 9 (18%) [90% CI (10.78–28.50%)] patients all of them were women. All but one was in a postpartum state. There was a single case of antiphospholipid antibody syndrome. Ten percent [90% CI (4.95–19.15%)] and 4% [90% CI (1.33–11.39%)] of patients were found to have rheumatic heart disease and systemic lupus erythematosus, respectively. One of the ischemic and hemorrhagic strokes was undiagnosed [90% CI (0.5–8.8%)]. Dyslipidemia as in elevated LDL and decreased HDL was a common finding. Dyslipidemia was found as the most common etiology for stroke in the young. Diagnostic challenges are to be expected while evaluating these patients.
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