{"title":"由编辑从本期杂志中选出的具有重要意义的文章","authors":"","doi":"10.1128/ec.00059-15","DOIUrl":null,"url":null,"abstract":"Mechanisms of Increased Susceptibility to Salmonella enterica Serovar Typhimurium Bacteremia in the Context of Malaria in African Children Salmonella enterica serovar Typhimurium bacteremia is known to be associated with malaria in African children. To understand the immunological basis of this association, Nyirenda et al. (e00057-17) investigated bactericidal immunity to S . Typhimurium in children with acute and convalescent uncomplicated malaria and in controls. They found that Plas-modium falciparum infection reduced serum bactericidal activity to S . Typhimurium and was associated with reduced complement C3, irrespective of preexisting specific-IgG antibody titers. P. falciparum infection also reduced whole-blood bactericidal activity to S . Typhimurium and was associated with reduction of neutrophil respiratory burst. These findings provide new insights into the increase in susceptibility to S . Typhimurium bacteremia in children from settings of malaria endemicity.","PeriodicalId":11891,"journal":{"name":"Eukaryotic Cell","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Article of Significant Interest Selected from This Issue by the Editors\",\"authors\":\"\",\"doi\":\"10.1128/ec.00059-15\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Mechanisms of Increased Susceptibility to Salmonella enterica Serovar Typhimurium Bacteremia in the Context of Malaria in African Children Salmonella enterica serovar Typhimurium bacteremia is known to be associated with malaria in African children. To understand the immunological basis of this association, Nyirenda et al. (e00057-17) investigated bactericidal immunity to S . Typhimurium in children with acute and convalescent uncomplicated malaria and in controls. They found that Plas-modium falciparum infection reduced serum bactericidal activity to S . Typhimurium and was associated with reduced complement C3, irrespective of preexisting specific-IgG antibody titers. P. falciparum infection also reduced whole-blood bactericidal activity to S . Typhimurium and was associated with reduction of neutrophil respiratory burst. These findings provide new insights into the increase in susceptibility to S . Typhimurium bacteremia in children from settings of malaria endemicity.\",\"PeriodicalId\":11891,\"journal\":{\"name\":\"Eukaryotic Cell\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eukaryotic Cell\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1128/ec.00059-15\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eukaryotic Cell","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/ec.00059-15","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Article of Significant Interest Selected from This Issue by the Editors
Mechanisms of Increased Susceptibility to Salmonella enterica Serovar Typhimurium Bacteremia in the Context of Malaria in African Children Salmonella enterica serovar Typhimurium bacteremia is known to be associated with malaria in African children. To understand the immunological basis of this association, Nyirenda et al. (e00057-17) investigated bactericidal immunity to S . Typhimurium in children with acute and convalescent uncomplicated malaria and in controls. They found that Plas-modium falciparum infection reduced serum bactericidal activity to S . Typhimurium and was associated with reduced complement C3, irrespective of preexisting specific-IgG antibody titers. P. falciparum infection also reduced whole-blood bactericidal activity to S . Typhimurium and was associated with reduction of neutrophil respiratory burst. These findings provide new insights into the increase in susceptibility to S . Typhimurium bacteremia in children from settings of malaria endemicity.
期刊介绍:
Eukaryotic Cell (EC) focuses on eukaryotic microbiology and presents reports of basic research on simple eukaryotic microorganisms, such as yeasts, fungi, algae, protozoa, and social amoebae. The journal also covers viruses of these organisms and their organelles and their interactions with other living systems, where the focus is on the eukaryotic cell. Topics include: - Basic biology - Molecular and cellular biology - Mechanisms, and control, of developmental pathways - Structure and form inherent in basic biological processes - Cellular architecture - Metabolic physiology - Comparative genomics, biochemistry, and evolution - Population dynamics - Ecology