由编辑从本期杂志中选出的具有重要意义的文章

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引用次数: 0

摘要

非洲儿童疟疾背景下肠炎沙门氏菌血清型鼠伤寒杆菌血症易感性增加的机制众所周知,肠炎沙门氏菌血清型鼠伤寒杆菌血症与非洲儿童疟疾有关。为了了解这种关联的免疫学基础,Nyirenda等人(e00057-17)研究了对S的杀菌免疫。急性和恢复期无并发症疟疾患儿和对照组的鼠伤寒。他们发现,恶性疟原虫感染使血清杀菌活性降低到S。鼠伤寒与补体C3减少有关,与预先存在的特异性igg抗体滴度无关。恶性疟原虫感染也使全血杀菌活性降低到S。鼠伤寒与中性粒细胞呼吸爆发减少有关。这些发现为S易感性的增加提供了新的见解。疟疾流行地区儿童的鼠伤寒菌血症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Article of Significant Interest Selected from This Issue by the Editors
Mechanisms of Increased Susceptibility to Salmonella enterica Serovar Typhimurium Bacteremia in the Context of Malaria in African Children Salmonella enterica serovar Typhimurium bacteremia is known to be associated with malaria in African children. To understand the immunological basis of this association, Nyirenda et al. (e00057-17) investigated bactericidal immunity to S . Typhimurium in children with acute and convalescent uncomplicated malaria and in controls. They found that Plas-modium falciparum infection reduced serum bactericidal activity to S . Typhimurium and was associated with reduced complement C3, irrespective of preexisting specific-IgG antibody titers. P. falciparum infection also reduced whole-blood bactericidal activity to S . Typhimurium and was associated with reduction of neutrophil respiratory burst. These findings provide new insights into the increase in susceptibility to S . Typhimurium bacteremia in children from settings of malaria endemicity.
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来源期刊
Eukaryotic Cell
Eukaryotic Cell 生物-微生物学
自引率
0.00%
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审稿时长
1 months
期刊介绍: Eukaryotic Cell (EC) focuses on eukaryotic microbiology and presents reports of basic research on simple eukaryotic microorganisms, such as yeasts, fungi, algae, protozoa, and social amoebae. The journal also covers viruses of these organisms and their organelles and their interactions with other living systems, where the focus is on the eukaryotic cell. Topics include: - Basic biology - Molecular and cellular biology - Mechanisms, and control, of developmental pathways - Structure and form inherent in basic biological processes - Cellular architecture - Metabolic physiology - Comparative genomics, biochemistry, and evolution - Population dynamics - Ecology
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