轻、重度COVID-19患者的实验室标志物和放射学征象

IF 0.2 Q4 RESPIRATORY SYSTEM
Hisham Abdel-Aaty, Mahmoud M. El-Habashy, I. Shedeed, A. Mahrous
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引用次数: 0

摘要

2019冠状病毒病(COVID-19)是一种全球大流行病,自2019年12月在中国武汉首次出现以来,已在全球范围内以惊人的方式传播。迄今为止,仍然缺乏一种适当的方案来预测即将发展为严重COVID-19的病例。因此,本工作旨在确定临床、实验室和放射学参数与COVID-19严重程度的潜在关联,以及这些参数预测严重病例的能力。患者和方法本研究是一项回顾性研究,数据来源于我院胸科门诊、胸科或ICU就诊的患者档案。该研究包括被诊断患有COVID-19的成年患者。患者分为重/危重症和轻/中度疾病两组。收集和分析患者病史、临床表现和放射学资料。结果本研究共纳入80例成人COVID-19患者。患者分为重/危重症(40例)和轻/中度疾病(40例)。COVID-19重症/危重型患者年龄明显偏大,合并症、患病率、咳嗽、呼吸困难、胃肠道症状和疲劳发生率均较高,白细胞总数升高、相对淋巴细胞降低、绝对淋巴细胞降低、中性粒细胞升高、血糖升高、谷丙转氨酶升高、天冬氨酸转氨酶升高、血清白蛋白降低、钙水平降低、乳酸脱氢酶升高、血清铁蛋白升高。d -二聚体和c反应蛋白水平。他们的计算机断层扫描(CT)评分明显较高,CT胸部病变大于50%或进展性病变。死亡率为10%,均为重症组。目前的研究证实,重症COVID-19与年龄、慢性疾病、CT成像模式、严重程度评分、白细胞计数、淋巴细胞减少、血糖、血清白蛋白、丙氨酸转氨酶、天冬氨酸转氨酶、钙水平、c反应蛋白、d -二聚体、乳酸脱氢酶和铁蛋白之间存在全面的实质性关联。这些结果突出了利用临床、实验室和放射学特征监测COVID-19患者的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Laboratory markers and radiological signs of mild versus severe COVID-19 patients
Background Coronavirus disease 2019 (COVID-19), a global pandemic that has spread worldwide in a dramatic manner since its first emergence in December 2019 from Wuhan, China. To date, there is still lack of an appropriate protocol that predicts cases who are impending to develop severe COVID-19. Hence, this work was an attempt to determine the potential association of the clinical, laboratory, and radiological parameters with the severity of COVID-19 and the ability of these parameters to predict the severe cases. Patients and methods This is a retrospective study that was based on recruiting the data from the files of patients who attended the chest outpatient clinic, or admitted to the chest department or the ICU of our institution. The study included adult patients who were diagnosed with COVID-19. Patients were categorized into two groups: severe/critical cases and mild/moderate disease cases. Data concerning the patient history, clinical picture, and radiological data were obtained and analyzed. Results Eighty adult patients with COVID-19 were included in this study. They were classified into severe/critical (40 patients) or mild/moderate disease (40 patients). Patients with severe/critical COVID-19 disease were significantly older in age and had higher comorbidities, prevalence, higher incidence of cough, dyspnea, gastrointestinal tract symptoms and fatigue, elevated total leukocyte count, lower relative lymphocytes, lower absolute lymphocytes and higher neutrophils, higher blood glucose levels, higher alanine transaminase, higher aspartate aminotransferase and lower serum albumin, reduced Ca levels, elevated lactate dehydrogenase, serum ferritin, D-dimer, and C-reactive protein levels. They had significantly higher computed tomographic (CT) scores and CT chest with greater than 50% lesions or progressive lesions. The mortality rate was 10%, all of which were from the severe disease group. Conclusion The current study is confirming an overall substantial association between severe COVID-19 and older age, chronic diseases, CT imaging pattern, and severity score, leukocyte count, lymphopenia, blood glucose, serum albumin, alanine transaminase, aspartate aminotransferase, calcium levels, C-reactive protein, D-dimer, lactate dehydrogenase, and ferritin. These results highlighted the importance of using clinical, laboratory, and radiological features for monitoring of COVID-19 patients.
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来源期刊
自引率
0.00%
发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
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