Dr. Cipto Mangunkusumo国立总医院结直肠腺癌临床病理特征与肿瘤萌芽状态的关系:回顾性研究

Ika Dhuhani, D. Handjari, N. Rahadiani, E. Krisnuhoni, Marini Stephanie
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引用次数: 0

摘要

背景:结直肠腺癌是最常见的恶性肿瘤之一。肿瘤萌芽(TB)状态与患者预后不良相关。预后受临床病理特征的影响。本研究旨在确定Dr. Cipto Mangunkusumo国立综合医院CA患者的临床病理特征与结核病状况之间的关系。方法:采用横断面回顾性分析研究,以解剖学病理科2019-2021年大肠恶性肿瘤切除术准备病例为辅助资料。根据纳入和排除标准,从所有病例中共抽取213份样本。采用卡方统计分析观察临床病理与结核状态的关系。结果:92例结核病以低分级为主。大多数病例年龄≥50岁(64.3%),男性(50.7%),位于左结肠(77.5%),组织病理程度低(85.9%),浸润深度在pT3(61.5%),淋巴血管浸润(LVI)(50.2%),淋巴结转移(52.6%),3期美国癌症联合委员会(AJCC)(42.3%),无神经周围浸润(PNI)(79.3%),无远处转移(82.6%)。统计分析检验显示,组织病理学程度、浸润深度、LVI、淋巴结转移、AJCC分期(p 0.001)与肿瘤位置(p = 0.036)有显著相关性。结论:结核状态与组织病理程度、LVI、淋巴结转移、浸润深度、AJCC分期及肿瘤部位有显著相关性。结核状态与PNI和远处器官转移无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between Clinicopathological Profile and Tumor Budding Status in Colorectal Adenocarcinoma at Dr. Cipto Mangunkusumo General National Hospital: A Retrospective Study
Background: Colorectal adenocarcinoma (CA) is one of the most common malignancies. Tumor budding (TB) status is associated with poor prognosis in patients. Prognosis is influenced by the clinicopathological profile. This study aims to determine the relationship between the clinicopathological profile with TB status in CA at Dr. Cipto Mangunkusumo General National Hospital.Method: A cross-sectional retrospective analytic study using secondary data in the form of cases in large bowel malignancy resection preparations at the Department of Anatomical Pathology in 2019-2021. A total of 213 samples were taken from all cases according to the inclusion and exclusion criteria. Chi square statistical analysis was performed to see the clinicopathological relationship with TB status.Results: Most common TB status were low grade with 92 cases. Most cases were ≥ 50 years old (64.3%), male (50.7%), located in the left colon (77.5%), histopathological degree low grade (85.9%), depth of invasion on pT3 (61.5%), lymphovascular invasion (LVI) (50.2%), lymph node metastasis (52.6%), stage 3 American Joint Committee on Cancer (AJCC (42.3%), without perineural invasion (PNI) (79.3%) and without distant metastases (82.6%). Statistical analysis test showed that there was a significant relationship between the degree of histopathology, depth of invasion, LVI, lymph node metastasis, and AJCC stage (p 0.001) and tumor location (p = 0.036).Conclusion: TB status was significantly related histopathological degree, LVI, lymph node metastasis, depth of invasion, AJCC stage, and tumor location. TB status was not associated with PNI and distant organ metastases. 
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