麦基那唑啉酮氨基酶衍生物的化学选择性合成及其x射线研究

Journal of Chemistry and Chemical Sciences Pub Date : 2019-03-04 DOI:10.29055/JCCS/703

R R Nuritdinova, E. B. Zh., O. R. Ya., K A Zakhidov, Tadjimukhamedov Kh.S.

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引用次数: 1

摘要

建立了生物碱麦基唑啉酮氨基酶衍生物的化学选择性合成方法，并对其晶体结构进行了研究。结果表明，硼氢化钠在室温下对希夫碱(中间体，4)的还原只选择性地通过还原亚甲胺(N=CH)键;其中不影响C=N双键。

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Chemoselective Synthesis of Aminobenzylic Derivative of Mackinazolinone and its X-ray Investigations

The method for chemoselective synthesis of aminobenzylic derivative of the alkaloid mackinazolinone was developed and studied its structurein the crystal. It was found that reduction of Schiff base (intermediate, 4) by sodium borohydride at room temperature goes selectively through reduction only of azomethine (N=CH) bond; wherein does not affect the C=N double bond.

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Journal of Chemistry and Chemical Sciences

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