整洁条件下4 A0分子筛介导间甲酚与手性胺的立体选择性氨基甲基化反应

The Open Catalysis Journal Pub Date : 2009-04-28 DOI:10.2174/1876214X00902010054

M. Gholizadeh

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引用次数: 0

摘要

在4A分子筛的整洁条件下，对甲酚羟基进行邻位甲基化。间甲酚与亚胺在无溶剂条件下，在600℃温度下进行一锅双组份Mannich反应，得到相应的胺甲基化产物，收率高，立体选择性适中。

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Stereoselective Aminomethylation of m-Cresol with Chiral Amine Mediated by 4 A0 Molecular Sieves Under Neat Conditions

A minomethylation at ortho position with respect to hydroxyl group of mcresol in presence carefully dried 4A molecular sieves under neat conditions. One pot, two component,Mannich reaction of m-cresol with imine at 600C temperature under solvent free conditions affords the corresponding aminomethylated products in good yields, with moderate stereoselectivity.

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The Open Catalysis Journal

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