罗勒叶提取物(ocum sanctum Linn.)、丁香酚和制霉菌素对引起HIV/AIDS患者口腔念珠菌病的念珠菌分离株的药敏比较

Emma Hidayati Sasmito, A. Hidayati, Rahmadewi, Sawitri, Budi Utomo, Sudjarwo, Pepy Dwi Endraswari, Diah Mira Indaramaya, Dwi Murtiastutik
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引用次数: 0

摘要

背景:口腔念珠菌病是由念珠菌引起的口腔黏膜感染,常见于HIV/AIDS患者。摘要目的:比较制霉菌素、罗勒叶提取物(Ocimum sanctum Linn.)和丁香酚对假丝酵母菌的抑菌敏感性,并对三种药物的抑菌敏感性进行比较。本研究比较了制霉菌素100 IU、丁香酚800µg/mL和400µg/mL剂量的罗勒叶提取物(Ocimum sanctum Linn.)以及丁香酚800µg/mL和400µg/mL剂量对40株HIV/AIDS患者口腔念珠菌的抑菌敏感性。结果:制霉菌素对各菌株的平均抑制带为22.98 mm,丁香酚800µg/mL和400µg/mL对制霉菌素的平均抑制带为17.07 mm和15.89 mm,丁香酚800µg/mL和400µg/mL对罗勒叶提取物的平均抑制带为14.87 mm和14.01 mm。罗勒叶提取物(Ocimum sanctum Linn.)和丁香酚的抑菌带显著低于制霉菌素(p = 0.001;P < 0.05)。结论:与罗勒叶提取物和丁香酚相比,制霉菌素对白色念珠菌和非白色念珠菌的抑制区明显增大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Antifungal Susceptibility Basil Leaves Extract (Ocimum sanctum Linn.), Eugenol, and Nystatin against Isolates of Candida spp. as Important Agent causing Oral Candidiasis in HIV/AIDS Patient
Background: Oral candidiasis is an infection caused by Candida sp. in areas of the oral mucosa that are often found in HIV/AIDS patients. Increased antifungal resistance, it was important to find new antifungal candidates, especially from natural ingredients, basil leaf extract (Ocimum sanctum Linn.) which had major compound of eugenol that had an antifungal effect in inhibiting of Candida sp. Purpose: To evaluate the comparison of the antifungal susceptibility of nystatin, basil leaf extract (Ocimum sanctum Linn.) and eugenol against isolates of Candida sp. Methods: This study examined the comparison of the antifungal susceptibility of nystatin 100 IU, basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol, and eugenol 800 µg/mL and 400 µg/mL against 40 stored isolates of Candida sp. from the oral cavity of HIV/AIDS patient which was reactivated. Result: The mean inhibition zone of nystatin for all isolates was 22.98 mm, while the mean inhibition zone of eugenol with doses of 800 µg/mL and 400 µg/mL were 17.07 mm and 15.89 mm, and the mean inhibition zone of basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol are 14.87 mm and 14.01 mm. The inhibition zone of basil leaf extract (Ocimum sanctum Linn.) and eugenol was significantly lower than nystatin (p = 0.001; p < 0.05). Conclusion: The zone of inhibition of nystatin was significantly higher compared to basil leaf extract (Ocimum sanctum Linn.) and eugenol against Candida albicans and Candida non-albicans isolates.
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