肝移植术后细菌并发症。有前景的进一步研究方向

U. R. Salimov, A. Shcherba, O. Rummo
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引用次数: 0

摘要

本文就肝移植术后早期细菌并发症的文献综述及肝移植术后细菌菌群影响的研究前景进行综述。本文介绍了各种细菌并发症的出现、传播、发病机制等问题,以及目前各种细菌并发症对肝移植结果影响的概念。给出了肝移植术后呼吸机相关性肺炎的结果。从微生物群对胆道树影响的角度对细菌并发症进行了理论分析。该评论还强调了一种相对较新的概念方法,即使用“机器学习方法”来检查科学研究的结果。在这篇文章中,所谓的CDC“四大”被选为主要的传染病术语。然而,导管相关的细菌并发症,其发病机制迄今已被充分研究,已被一组相对较新的并发症-细菌胆汁所取代。本综述还包含在NCT04281797研究框架中收集的简要统计数据。自己的队列数据包括57例接受了来自死后供体的原位肝移植的患者。手术部位感染是术后早期最常见的细菌并发症。细菌感染最常见的病原体是肺炎克雷伯菌和肠球菌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bacterial complications after liver transplantation. Promising directions for further research
This article is presented in form of a current literature review on bacterial complications of the early post-liver transplantation period and promising areas for studying the effect of bacterial flora in patients after liver transplantation. The paper describes the problem of the emergence, spread, and pathogenesis of various bacterial complications, as well as current concepts of various bacterial complication’s impact on the results of liver transplantation. The results of ventilatorassociated pneumonia in patients after liver transplantation are given. A theoretical analysis of bacterial complications from the standpoint of microbiota effects on the biliary tree was carried out. The review also highlights a relatively new conceptual approach in examining the results of scientific research using the "Machine Learning Method”. The so-called CDC “Big Four” was chosen as the main infectious nomenclature in this article. However, catheter-associated bacterial complications, which pathogenesis has been sufficiently studied to date, have been replaced by a relatively new group of complications – bacteriobilia. This review also contains a brief statistical data collected in the frames of the NCT04281797 study. Own cohort data consisted of 57 patients who underwent orthotopic liver transplantation from a post-mortem donor. Surgical site infection was the most common bacterial complication of the early postoperative period. The most common causative agent of bacterial infection was Klebsiella pneumonia and Enterococcus.
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