外阴阴道激光治疗的证据:确保我们不会重复过去的错误

Sophia Song, A. Budden, Asha Short, E. Nesbitt-Hawes, R. Deans, J. Abbott
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引用次数: 26

摘要

绝经后,多达49%的女性会因雌激素缺乏而出现阴道瘙痒、干燥、性交困难和尿失禁等泌尿生殖系统症状。阴道润滑剂和保湿剂等治疗只能暂时缓解症状,而局部雌激素治疗对许多妇女来说往往是不可接受的或不安全的。最近,一种新的激光治疗被提出,作为一种非侵入性的、长期的解决外阴阴道和泌尿系统症状的方法。虽然初步的组织学结果很有希望,但其治疗和临床效果尚未确定。然而,尽管缺乏其安全性和长期益处的证据,激光治疗被广泛推广用于一系列泌尿生殖系统症状,临床医生和女性都有很高的接受度。本综述旨在研究激光治疗外阴阴道的证据,并评价其安全性和有效性。我们的研究结果包括17项关于激光治疗外阴阴道症状的研究,7项关于其对尿失禁的影响,4项关于组织学的研究。这些研究仅限于非随机的观察性数据,样本量在15至175名女性之间,随访时间从0到2年不等。因此,激光有效性和安全性的有力证据是有限的,需要在广泛应用之前进行更有力的安慰剂对照随机试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The evidence for laser treatments to the vulvo‐vagina: Making sure we do not repeat past mistakes
Following menopause, up to 49% of women will experience genitourinary symptoms such as vaginal itching, dryness, dyspareunia and incontinence as a result of oestrogen deficiency. Treatments such as vaginal lubricants and moisturisers only temporarily relieve symptoms, while local oestrogen treatments are often unacceptable or unsafe for many women. Recently, a novel laser treatment has been proposed as a non‐invasive, long‐term solution to vulvo‐vaginal and urinary symptoms. While preliminary histological results have been promising, its therapeutic, clinical effect has yet to be determined. However, despite the scarcity of evidence for its safety and long‐term benefit, laser treatments are widely marketed for a range of genitourinary symptoms, with high uptake by both clinicians and women alike. This review aims to examine the evidence for laser treatments to the vulvo‐vagina and to evaluate its safety and efficacy. Our results include 17 studies investigating the effect of laser therapy for vulvo‐vaginal symptoms, seven for its effects on urinary incontinence and four for histology. These are limited to non‐randomised, observational data with small sample sizes between 15 to 175 women and follow‐up duration from none to two years. As such, strong evidence for laser efficacy and safety is limited and warrants more robust, placebo‐controlled, randomised trials before widespread implementation.
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