2010-2019年哈萨克斯坦共和国骨肉瘤的临床和流行病学特征

D. Tuleuova, G. Serikbayev, А. Kurmanalyev, Z. Pyssanova, А. Yelekbayev
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This urges to determine the prognostic factors of the disease, timely assess the treatment effect, and identify \npossible relapses. \nThe study aimed to improve the early diagnosis of bone sarcomas, to improve and increase the oncological alertness of doctors by establishing \nthe trends in bone sarcoma incidence and mortality in the Republic of Kazakhstan in 2010-2019, and this disease incidence and mortality in 2019 \nby age, gender, bone tumor histotype and region of the country. \nMethods: The study included the data of patients registered at the RK National Cancer Registry in 2010-2019 with a “bone sarcoma” diagnosis (ICD-10 code: C40-C41). The incidence of bone sarcomas was presented as absolute and crude rates per 100,000 population. Absolute \nstandardized morbidity and mortality were calculated using the World Standard. MS Excel 2016 was used to display the results graphically. \nResults: By the end of 2019, 1587 patients were registered with bone sarcomas in the RK. 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摘要

相关性:肉瘤是一种异质性的间质恶性肿瘤(MNs)。骨肿瘤的发病率高峰出现在一个具有社会意义的年龄段:骨肉瘤和尤文氏肉瘤为10-25岁,软骨肉瘤为35-40岁。骨肉瘤是人类恶性肿瘤中最具侵袭性的。这促使我们确定疾病的预后因素,及时评估治疗效果,并识别可能的复发。本研究旨在通过建立2010-2019年哈萨克斯坦共和国骨肉瘤发病率和死亡率的趋势,以及2019年该国按年龄、性别、骨肿瘤组织类型和地区划分的骨肉瘤发病率和死亡率,提高骨肉瘤的早期诊断,改善和提高医生的肿瘤警觉性。方法:本研究纳入了2010-2019年在RK国家癌症登记处登记的诊断为“骨肉瘤”的患者数据(ICD-10代码:C40-C41)。骨肉瘤的发病率以每10万人的绝对发病率和粗发病率表示。绝对标准化发病率和死亡率采用世界标准计算。使用MS Excel 2016对结果进行图形化显示。结果:截至2019年底,RK共登记了1587例骨肉瘤患者。从2010年到2019年,RK的骨肉瘤发病率下降了39%,其中男性下降了36%,女性下降了40%。死亡率下降37%,降至每10万人0.8%。骨肉瘤不在英国最常见的20种癌症之列;它占所有MN新发病例(2010-2019年)的0.7%。骨肉瘤的发病率高峰在20岁以下(20%),死亡率高峰在45-54岁年龄组(22%)。结论:骨MNs罕见,可引起初检时的误诊。骨肉瘤占韩国诊断的所有MNs的0.8%;然而,病程的侵袭性和快速的血液转移导致在初次就诊时忽视本病的比例很高。此外,骨肉瘤在年轻成人和青少年中比其他MNs更常见。原发性骨肉瘤的预后取决于许多因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF BONE SARCOMAS IN THE REPUBLIC OF KAZAKHSTAN IN 2010-2019
Relevance: Sarcomas are a heterogeneous group of malignant neoplasms (MNs) of mesenchymal origin. The peak incidence of bone tumors falls on a socially significant age: with osteosarcoma and Ewing’s sarcoma – 10-25 years, with chondrosarcoma – 35-40 years. Bone sarcomas are the most aggressive human MNs. This urges to determine the prognostic factors of the disease, timely assess the treatment effect, and identify possible relapses. The study aimed to improve the early diagnosis of bone sarcomas, to improve and increase the oncological alertness of doctors by establishing the trends in bone sarcoma incidence and mortality in the Republic of Kazakhstan in 2010-2019, and this disease incidence and mortality in 2019 by age, gender, bone tumor histotype and region of the country. Methods: The study included the data of patients registered at the RK National Cancer Registry in 2010-2019 with a “bone sarcoma” diagnosis (ICD-10 code: C40-C41). The incidence of bone sarcomas was presented as absolute and crude rates per 100,000 population. Absolute standardized morbidity and mortality were calculated using the World Standard. MS Excel 2016 was used to display the results graphically. Results: By the end of 2019, 1587 patients were registered with bone sarcomas in the RK. From 2010 to 2019, the incidence of bone sarcoma in the RK decreased by 39%, including 36% among men and 40% among women. Mortality decreased by 37% to 0.8% per 100,000 population. Bone sarcoma is not among the 20 most common types of cancer in the RK; it accounts for 0.7% of all new cases of MN (2010-2019). The peak incidence of bone sarcoma was observed at the age below 20 years (20%), and mortality – in the age group of 45-54 years (22%). Conclusion: The rare occurrence of bone MNs can cause misdiagnosis during the initial examination. Bone sarcomas account for 0.8% of all MNs diagnosed in the RK; however, the aggressiveness of the course and rapid hematogenous metastasis causes a high percentage of neglect of this disease during the initial visit. In addition, bone sarcomas are more common than other MNs in young adults and adolescents. The prognosis of primary bone sarcomas depends on many factors.
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