{"title":"半乳糖呋喃基化半乳糖脑苷:一种新的神经酰胺结肠给药系统","authors":"D. Iga, Silvia Iga","doi":"10.2174/1874095200801020046","DOIUrl":null,"url":null,"abstract":"Two isomeric partially acetylated galactocerebrosides, s-D-galactopyranosyl (2,3,4-tri-O-acetyl)- and s-D- galactopyranosyl (2,4,6-tri-O-acetyl)-1'(3'-O-acetyl)ceramide, were prepared from galactocerebroside and sulfatide, re- spectively. Their galactofuranosylation produced s-D-galactofuranosyl-6- and s-D-galactofuranosyl-3-s-D- galactopyranosyl-1'ceramide, as demonstrated by 1 H and 13 C NMR spectra as well as by chemical means. 1 H and 13 C NMR spectroscopy.","PeriodicalId":23020,"journal":{"name":"The Open Organic Chemistry Journal","volume":"1 1","pages":"46-51"},"PeriodicalIF":0.0000,"publicationDate":"2008-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Galactofuranosylated Galactocerebrosides, a New Drug Delivery System for Ceramides to Colon\",\"authors\":\"D. Iga, Silvia Iga\",\"doi\":\"10.2174/1874095200801020046\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Two isomeric partially acetylated galactocerebrosides, s-D-galactopyranosyl (2,3,4-tri-O-acetyl)- and s-D- galactopyranosyl (2,4,6-tri-O-acetyl)-1'(3'-O-acetyl)ceramide, were prepared from galactocerebroside and sulfatide, re- spectively. Their galactofuranosylation produced s-D-galactofuranosyl-6- and s-D-galactofuranosyl-3-s-D- galactopyranosyl-1'ceramide, as demonstrated by 1 H and 13 C NMR spectra as well as by chemical means. 1 H and 13 C NMR spectroscopy.\",\"PeriodicalId\":23020,\"journal\":{\"name\":\"The Open Organic Chemistry Journal\",\"volume\":\"1 1\",\"pages\":\"46-51\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Organic Chemistry Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874095200801020046\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Organic Chemistry Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874095200801020046","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
以半乳糖脑苷和硫脂分别制备了2种半乳糖脑苷同分异构体部分乙酰化的s-D-半乳糖脑苷(2,3,4-三- o -乙酰基)和s-D-半乳糖脑苷(2,4,6-三- o -乙酰基)-1′(3′- o -乙酰基)神经酰胺。他们的半乳糖呋喃基化产生了s- d -半乳糖呋喃基-6和s- d -半乳糖呋喃基-3-s- d -半乳糖吡喃基-1'神经酰胺，通过1h和13c核磁共振光谱以及化学方法证明。1h和13c核磁共振光谱。
Galactofuranosylated Galactocerebrosides, a New Drug Delivery System for Ceramides to Colon
Two isomeric partially acetylated galactocerebrosides, s-D-galactopyranosyl (2,3,4-tri-O-acetyl)- and s-D- galactopyranosyl (2,4,6-tri-O-acetyl)-1'(3'-O-acetyl)ceramide, were prepared from galactocerebroside and sulfatide, re- spectively. Their galactofuranosylation produced s-D-galactofuranosyl-6- and s-D-galactofuranosyl-3-s-D- galactopyranosyl-1'ceramide, as demonstrated by 1 H and 13 C NMR spectra as well as by chemical means. 1 H and 13 C NMR spectroscopy.
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