R. Ouedraogo, J. Fontaine, M. Antoine, B. Pirotte, P. Lebrun
{"title":"3-烷基胺-7-氯- 4h -吡啶[2,3-e]-1,2,4-噻二嗪1,1-二氧化物对平滑肌收缩活性的影响","authors":"R. Ouedraogo, J. Fontaine, M. Antoine, B. Pirotte, P. Lebrun","doi":"10.1211/146080800128735700","DOIUrl":null,"url":null,"abstract":"New 3-alkylaminopyridothiadiazine dioxides have been synthesized and characterized in a search for more efficient and selective KATP-channel activators. \n \n \n \nThe new compounds induced concentration-dependent relaxation of vascular (aorta) and gastrointestinal (ileum) smooth muscle. The pharmacological profiles of the new compounds were different from those of diazoxide or pinacidil but similar to that of verapamil. \n \n \n \nThe results suggest that the myorelaxant properties of the new compounds depend on their capacity to reduce calcium inflow into smooth muscle cells.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Effects of 3-alkylamino-7-chloro-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides on smooth muscle contractile activity\",\"authors\":\"R. Ouedraogo, J. Fontaine, M. Antoine, B. Pirotte, P. Lebrun\",\"doi\":\"10.1211/146080800128735700\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"New 3-alkylaminopyridothiadiazine dioxides have been synthesized and characterized in a search for more efficient and selective KATP-channel activators. \\n \\n \\n \\nThe new compounds induced concentration-dependent relaxation of vascular (aorta) and gastrointestinal (ileum) smooth muscle. The pharmacological profiles of the new compounds were different from those of diazoxide or pinacidil but similar to that of verapamil. \\n \\n \\n \\nThe results suggest that the myorelaxant properties of the new compounds depend on their capacity to reduce calcium inflow into smooth muscle cells.\",\"PeriodicalId\":19946,\"journal\":{\"name\":\"Pharmacy and Pharmacology Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacy and Pharmacology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1211/146080800128735700\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080800128735700","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of 3-alkylamino-7-chloro-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides on smooth muscle contractile activity
New 3-alkylaminopyridothiadiazine dioxides have been synthesized and characterized in a search for more efficient and selective KATP-channel activators.
The new compounds induced concentration-dependent relaxation of vascular (aorta) and gastrointestinal (ileum) smooth muscle. The pharmacological profiles of the new compounds were different from those of diazoxide or pinacidil but similar to that of verapamil.
The results suggest that the myorelaxant properties of the new compounds depend on their capacity to reduce calcium inflow into smooth muscle cells.
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