易带电的sars-cov-2点,病毒的电模型和微量元素在其失活中的作用

V. Kaplunenko, N.V. Kosinov, A. Skalny
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引用次数: 0

摘要

在这篇综述文章中,认为病毒表面的带电分子基团可以作为抗病毒药物的靶点。展望了微量元素在低氧化态下作为抗病毒药物的应用前景。SARS-CoV-2的电模型已经以多层结构的形式开发出来,其中每个外壳对应于病毒表面的带电蛋白质。该模型揭示了库仑力在吸附和融合过程中的作用,并使识别冠状病毒中对带电物质和电场敏感的脆弱性成为可能。揭示了微量元素的抗病毒作用机制,其原理是通过中和病毒和细胞表面的电荷来抑制病毒与细胞的静电相互作用。这允许选择低氧化态的寡肽和微量元素来抑制病毒的吸附能力。微量元素的特殊作用在于,许多抗体和其他大分子无法接近的潜在靶点,都很容易被微量元素利用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
VULNERABLE ELECTRICALLY CHARGED SARS-COV-2 POINTS, ELECTRIC MODEL OF THE VIRUS AND ROLE OF TRACE ELEMENTS IN ITS INACTIVATION
In the review article, electrically charged molecular groups on the surface of the virus were considered as targets for antiviral agents. The prospects of trace element application in a low oxidation state as antiviral agents have been shown. An electrical model of SARS-CoV-2 has been developed in the form of a multilayer structure, where each shell corresponds to electrically charged proteins on the surface of the virus. The model reveals the role of Coulomb forces in adsorption and fusion processes and makes it possible to identify vulnerabilities in the coronavirus that are sensitive to electrically charged substances and to an electric field. The mechanism of antiviral action of trace elements is disclosed, based on the suppression of electrostatic interaction of virus with the cell by neutralizing the charges on the surface of the virus and the cell. This allows the selection of oligopeptides and trace elements in low oxidation states to suppress the adsorption capacity of viruses. The special role of trace elements is that many potential targets that are inaccessible to antibodies and other large molecules are easily available to trace elements.
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