Mesenchymal Stem Cells and Their Derivatives for Skin Rejuvenation

Skin aging is a process in which the collagen and elastin in the dermis layer of human skin gradually get lost as time passes, resulting in wrinkles and lack of resilience of the skin. As people’s aesthetic standards have constantly grown in the recent years, many tried to eliminate wrinkles to improve their appearance; consequently, the demand for anti-aging has as well increased in the market. In the wide research for anti-aging, multipotent mesenchymal stem cells (MSCs) found in various sources including bone marrow, adipose tissue, umbilical cord and umbilical cord blood have been proved to eliminate wrinkles effectively by helping to promote collagen and elastin in the skin. In addition, MSCs also receive little or no response from human immune system, which is ideal for donor MSCs to be transplanted to other patients. In both preclinical and clinical studies, MSCs and their derivatives (such as MSC-derived conditioned medium and extracellular vesicles) have been proven to be beneficial in skin rejuvenation. This article specifically focuses on the recent advances in MSCs and MSCs-derivatives for skin rejuvenation.