间充质干细胞及其皮肤再生衍生物

Jessica Hu, J. Hao
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引用次数: 0

摘要

皮肤老化是人体皮肤真皮层中的胶原蛋白和弹性蛋白随着时间的推移逐渐丢失,导致皮肤出现皱纹,缺乏弹性的过程。近年来,随着人们的审美标准不断提高,许多人都试图消除皱纹来改善自己的外表;因此,市场对抗衰老的需求也增加了。在广泛的抗衰老研究中,从骨髓、脂肪组织、脐带和脐带血中发现的多能间充质干细胞(MSCs)已被证明可以有效地消除皱纹,帮助促进皮肤中的胶原蛋白和弹性蛋白。此外,骨髓间充质干细胞对人体免疫系统的反应很少或没有反应,这是骨髓间充质干细胞移植到其他患者身上的理想条件。在临床前和临床研究中,间充质干细胞及其衍生物(如间充质干细胞衍生的条件培养基和细胞外囊泡)已被证明有益于皮肤年轻化。本文重点介绍了间充质干细胞及其衍生物在皮肤年轻化方面的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mesenchymal Stem Cells and Their Derivatives for Skin Rejuvenation
Skin aging is a process in which the collagen and elastin in the dermis layer of human skin gradually get lost as time passes, resulting in wrinkles and lack of resilience of the skin. As people’s aesthetic standards have constantly grown in the recent years, many tried to eliminate wrinkles to improve their appearance; consequently, the demand for anti-aging has as well increased in the market. In the wide research for anti-aging, multipotent mesenchymal stem cells (MSCs) found in various sources including bone marrow, adipose tissue, umbilical cord and umbilical cord blood have been proved to eliminate wrinkles effectively by helping to promote collagen and elastin in the skin. In addition, MSCs also receive little or no response from human immune system, which is ideal for donor MSCs to be transplanted to other patients. In both preclinical and clinical studies, MSCs and their derivatives (such as MSC-derived conditioned medium and extracellular vesicles) have been proven to be beneficial in skin rejuvenation. This article specifically focuses on the recent advances in MSCs and MSCs-derivatives for skin rejuvenation.
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