人牙周韧带干细胞(PDLSC)在牙周炎中的局部免疫调节:系统综述

Jamil Ahsan Kazi, Erni Noor, Nurshafiqah Zahra Mohd Azmi, Wan Nur Nadhirah Wan Azmi
{"title":"人牙周韧带干细胞(PDLSC)在牙周炎中的局部免疫调节:系统综述","authors":"Jamil Ahsan Kazi, Erni Noor, Nurshafiqah Zahra Mohd Azmi, Wan Nur Nadhirah Wan Azmi","doi":"10.24191/cos.v10i2.23637","DOIUrl":null,"url":null,"abstract":"Background: Human periodontal ligament stem cells (PDLSC) are multipotent cells, derived from periodontal ligament (PDL), that can attain the formation of new bone, cementum, and periodontal ligament. However, the quantity of stem cells found in PDL tissues is deficient. Therefore, in periodontitis, the limited PDLSCs make regeneration of the periodontium challenging and unpredictable. Objectives: To critically appraise the available experimental evidence of the local immunomodulation signaling systems and their surrounding functional molecules for repair and application in periodontal regeneration therapy. Methods: This systematic review was conducted using PRISMA 2020 guidelines and research papers were selected based on strict exclusion and inclusion criteria. PubMed, Cochrane Library, Google Scholar and Web of Science databases were used to collect all the research papers ranging from January 2012 to December 2022. Results: Nine out of 586 research papers that focused on PDLSCs during inflammatory conditions were selected based on the Cochrane Risk of Bias Assessment. Seven articles documented that non-coding microRNAs (ncRNAs) played critical roles in the modification of PDLSC multipotency in periodontitis. An article showed that the post-translational modifications are influenced by histone deacetylases (HDAC) indicating the involvement of novel epigenetic signaling systems. A natural product-derived functional molecule resveratrol is described to have anti-inflammatory properties through the nuclear factor kappa B (NF-kB) pathway. Conclusion: The results of our present systematic review clearly apprise that the ncRNAs signaling system and natural products derived anti-inflammatory functional molecules play a clinically significant therapeutic target in novel periodontitis therapy as preventive, diagnostic, therapeutic, and prognostic markers.","PeriodicalId":10525,"journal":{"name":"Compendium of Oral Science","volume":"89 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Local Immunomodulation of Human Periodontal Ligaments Stem Cells (PDLSC) in Periodontitis: A Systematic Review\",\"authors\":\"Jamil Ahsan Kazi, Erni Noor, Nurshafiqah Zahra Mohd Azmi, Wan Nur Nadhirah Wan Azmi\",\"doi\":\"10.24191/cos.v10i2.23637\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Human periodontal ligament stem cells (PDLSC) are multipotent cells, derived from periodontal ligament (PDL), that can attain the formation of new bone, cementum, and periodontal ligament. However, the quantity of stem cells found in PDL tissues is deficient. Therefore, in periodontitis, the limited PDLSCs make regeneration of the periodontium challenging and unpredictable. Objectives: To critically appraise the available experimental evidence of the local immunomodulation signaling systems and their surrounding functional molecules for repair and application in periodontal regeneration therapy. Methods: This systematic review was conducted using PRISMA 2020 guidelines and research papers were selected based on strict exclusion and inclusion criteria. PubMed, Cochrane Library, Google Scholar and Web of Science databases were used to collect all the research papers ranging from January 2012 to December 2022. Results: Nine out of 586 research papers that focused on PDLSCs during inflammatory conditions were selected based on the Cochrane Risk of Bias Assessment. Seven articles documented that non-coding microRNAs (ncRNAs) played critical roles in the modification of PDLSC multipotency in periodontitis. An article showed that the post-translational modifications are influenced by histone deacetylases (HDAC) indicating the involvement of novel epigenetic signaling systems. A natural product-derived functional molecule resveratrol is described to have anti-inflammatory properties through the nuclear factor kappa B (NF-kB) pathway. Conclusion: The results of our present systematic review clearly apprise that the ncRNAs signaling system and natural products derived anti-inflammatory functional molecules play a clinically significant therapeutic target in novel periodontitis therapy as preventive, diagnostic, therapeutic, and prognostic markers.\",\"PeriodicalId\":10525,\"journal\":{\"name\":\"Compendium of Oral Science\",\"volume\":\"89 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Compendium of Oral Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24191/cos.v10i2.23637\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Compendium of Oral Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24191/cos.v10i2.23637","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:人牙周韧带干细胞(PDLSC)是来源于牙周韧带(PDL)的多能细胞,能够形成新的骨、牙骨质和牙周韧带。然而,在PDL组织中发现的干细胞数量不足。因此,在牙周炎中,有限的PDLSCs使牙周组织的再生具有挑战性和不可预测性。目的:批判性地评价局部免疫调节信号系统及其周围功能分子在牙周再生治疗中的修复和应用的现有实验证据。方法:本系统评价采用PRISMA 2020指南,并根据严格的排除和纳入标准筛选研究论文。使用PubMed、Cochrane Library、b谷歌Scholar和Web of Science数据库收集2012年1月至2022年12月期间的所有研究论文。结果:根据Cochrane偏倚风险评估,从586篇关注炎症状态下PDLSCs的研究论文中选择了9篇。七篇文章证明,非编码microRNAs (ncRNAs)在牙周炎中PDLSC多能性修饰中起关键作用。一篇文章表明,翻译后修饰受到组蛋白去乙酰化酶(HDAC)的影响,表明涉及新的表观遗传信号系统。一种天然产物衍生的功能分子白藜芦醇通过核因子κ B (NF-kB)途径具有抗炎特性。结论:本系统综述的结果清楚地表明,ncRNAs信号系统和天然产物衍生的抗炎功能分子作为预防、诊断、治疗和预后标志物,在新型牙周炎治疗中发挥着重要的临床治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Local Immunomodulation of Human Periodontal Ligaments Stem Cells (PDLSC) in Periodontitis: A Systematic Review
Background: Human periodontal ligament stem cells (PDLSC) are multipotent cells, derived from periodontal ligament (PDL), that can attain the formation of new bone, cementum, and periodontal ligament. However, the quantity of stem cells found in PDL tissues is deficient. Therefore, in periodontitis, the limited PDLSCs make regeneration of the periodontium challenging and unpredictable. Objectives: To critically appraise the available experimental evidence of the local immunomodulation signaling systems and their surrounding functional molecules for repair and application in periodontal regeneration therapy. Methods: This systematic review was conducted using PRISMA 2020 guidelines and research papers were selected based on strict exclusion and inclusion criteria. PubMed, Cochrane Library, Google Scholar and Web of Science databases were used to collect all the research papers ranging from January 2012 to December 2022. Results: Nine out of 586 research papers that focused on PDLSCs during inflammatory conditions were selected based on the Cochrane Risk of Bias Assessment. Seven articles documented that non-coding microRNAs (ncRNAs) played critical roles in the modification of PDLSC multipotency in periodontitis. An article showed that the post-translational modifications are influenced by histone deacetylases (HDAC) indicating the involvement of novel epigenetic signaling systems. A natural product-derived functional molecule resveratrol is described to have anti-inflammatory properties through the nuclear factor kappa B (NF-kB) pathway. Conclusion: The results of our present systematic review clearly apprise that the ncRNAs signaling system and natural products derived anti-inflammatory functional molecules play a clinically significant therapeutic target in novel periodontitis therapy as preventive, diagnostic, therapeutic, and prognostic markers.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信