用扫描磁共振成像研究聚合物凝胶的温度依赖性

H. Kawamura, K. Shinoda, H. Fuse, T. Takanashi, Y. Shimada, Y. Ishimori, M. Monma, K. Miyamoto, H. Sato, T. Fujisaki, T. Sakae, A. Matsumura
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引用次数: 1

摘要

聚合物凝胶是三维剂量测定工具。本研究的目的是研究聚合物凝胶在扫描磁共振成像过程中的温度依赖性。用6MV x射线束照射制备的凝胶,强度从0到20 Gy,以研究它们的剂量- r2和剂量- r1响应。从5°C到41°C,温度每变化5°C,从1.5 t磁共振R2和R1图像对辐照凝胶进行评价,然后采用四场箱技术辐照计划,以相同的束重在每个方向向制备的凝胶输送总剂量为4 Gy。然后将20°C下四场辐照凝胶数据生成的剂量图剖面与计划数据进行比较。在20°C下,剂量- r2响应曲线在20 Gy范围内呈线性,斜率为1.17 Gy-1ds-1。剂量- r2拟合曲线的斜率随凝胶温度的升高而减小。在5 ~ 41℃范围内,剂量- r1曲线的斜率比剂量- r2曲线的斜率更平行。在20°C条件下,采用四场箱法获得的凝胶剖面数据与计划数据的半最大值全宽度差平均小于5%。在相同温度条件下,使用剂量- r2曲线得到的辐照凝胶剂量图与计划数据相同。测量不同温度之间的差异具有剂量精度。从辐照凝胶的稳定性角度出发,适合在热平衡条件下、MRI室温下对凝胶剂量计进行评价。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of Temperature Dependence of Polymer Gels for Use with Scanning Magnetic Resonance Imaging
Polymer gels are three-dimensional dosimetric tools. The purpose of the present study was to investigate the temperature dependence of polymer gels during scanning Magnetic Resonance Imaging. Prepared gels were irradiated with a 6MV X-ray beam at intensities ranging from 0 to 20 Gy in order to investigate their dose-R2 and dose-R1 responses. Irradiated gels were evaluated from 1.5-T magnetic resonance R2 and R1 images for each 5°C change in temperature from 5°C to 41°C, and then the four-field box technique irradiation plan was used to deliver a total dose of 4 Gy using the same beam weight in each direction to the prepared gels. The profile of the dose map generated from the four-field irradiated gel data at 20°C was then compared with the planned data. The dose-R2 response curve was linear up to 20 Gy at 20°C, with a slope of 1.17 Gy-1ds-1. The slopes of the fitted curves of the dose-R2 decreased as gel temperature increased. The slopes of the dose-R1 curves were more parallel than the slopes of the dose-R2 curves between 5 and 41°C. The difference in the full width of half maximum of the gel profile data obtained using the four-field box technique at 20°C and the planned data were below 5% on average. The dose map from the irradiated gels obtained using the dose-R2 curve was the same as that from the planned data under the same temperature conditions. Measurement of difference between various temperatures is significant with dose accuracy. It is suitable to evaluate the gel dosimeter under the thermal equilibrium condition, MRI room temperature from the point of view of the stability of the irradiated gels.
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