细胞外囊泡生物标志物的筛选策略及临床验证

Q4 Health Professions

中华检验医学杂志 Pub Date : 2020-02-11 DOI:10.3760/CMA.J.ISSN.1009-9158.2020.02.002

Bo Wu, Hang Zhang, Taixue An

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引用次数: 0

摘要

细胞外囊泡(Extracellular vesicles, EVs)是细胞间相互作用的基本途径之一，携带大量生物物质，在疾病诊断和治疗方面具有巨大潜力。与组织活检相比，其检测具有无创、采样方便、实时监测等优点。因此，电动汽车生物标志物的研究和临床应用已成为国际上的研究热点。为鼓励电动汽车生物标志物筛选和检测技术的发展，有效提高电动汽车生物标志物诊断的准确性，促进电动汽车生物标志物研究成果转化为疾病的临床应用，本文综述了电动汽车在疾病诊断中的意义及其生物标志物筛选策略和临床验证。关键词:细胞外囊泡;生物标志物;临床检验技术;验证研究

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Screening strategy and clinical validation of extracellular vesicle biomarkers

Extracellular vesicles (EVs), one of the basic ways of intercellular interactions, carry a large number of biological substances and show great potential in disease diagnosis and treatment. Compared with tissue biopsy, its detection has the advantages of non-invasive, convenient sampling and real-time monitoring. Therefore, the research and clinical application of EVs biomarkers have become an international research hotspot. In order to encourage the development of screening and detection technologies for EVs biomarkers, effectively improve the accuracy of EVs biomarker diagnosis, and promote the transformation of EVs biomarker research results into the clinical application of disease, this review summarizes the significance of EVs in disease diagnosis and its biomarker screening strategy and clinical validation. Key words: Extracellular vesicles; Biomarkers; Clinical laboratory techniques; Validation studies

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来源期刊

中华检验医学杂志 Health Professions-Medical Laboratory Technology

CiteScore

0.40

自引率

0.00%

发文量

8037

期刊介绍：