Y. V. Khasanova, A. B. Galkina, A. Nelaeva, Medvedeva
{"title":"2型糖尿病和糖尿病肾病患者脂质代谢及促炎细胞因子水平与慢性肾病分期的关系","authors":"Y. V. Khasanova, A. B. Galkina, A. Nelaeva, Medvedeva","doi":"10.4172/2161-1017.1000294","DOIUrl":null,"url":null,"abstract":"Purpose: Study of the role and relationship of lipid metabolism parameters and level of pro-inflammatory cytokines in patients with type-2 diabetes with diabetic nephropathy (DN) depending on the stage of chronic kidney disease (CKD). Materials and methods: 240 patients with type-2 diabetes were examined in the early stages of DN and CKD. Results: The development of DN was accompanied by an increase in the level of pro-inflammatory cytokines and impaired lipid metabolism (hypertriglyceridemia) in patients with type 2 diabetes. A negative correlation was found between the level of triglycerides (TG) and the glomerular filtration rate (GFR) (r=-0.43) and a direct relationship between the level of IL-6 and TG (r=0.48). Findings: An increase in the level of pro-inflammatory cytokines and TG increases the risk of the development and progression of DN and CKD.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"358 1","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Features of Lipid Metabolism and Level of Pro-inflammatory Cytokines in Patients with Type-2 Diabetes and with Diabetic Nephropathy Depending on the Stage of Chronic Kidney Disease\",\"authors\":\"Y. V. Khasanova, A. B. Galkina, A. Nelaeva, Medvedeva\",\"doi\":\"10.4172/2161-1017.1000294\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose: Study of the role and relationship of lipid metabolism parameters and level of pro-inflammatory cytokines in patients with type-2 diabetes with diabetic nephropathy (DN) depending on the stage of chronic kidney disease (CKD). Materials and methods: 240 patients with type-2 diabetes were examined in the early stages of DN and CKD. Results: The development of DN was accompanied by an increase in the level of pro-inflammatory cytokines and impaired lipid metabolism (hypertriglyceridemia) in patients with type 2 diabetes. A negative correlation was found between the level of triglycerides (TG) and the glomerular filtration rate (GFR) (r=-0.43) and a direct relationship between the level of IL-6 and TG (r=0.48). Findings: An increase in the level of pro-inflammatory cytokines and TG increases the risk of the development and progression of DN and CKD.\",\"PeriodicalId\":11670,\"journal\":{\"name\":\"Endocrinology and Metabolic Syndrome\",\"volume\":\"358 1\",\"pages\":\"1-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrinology and Metabolic Syndrome\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2161-1017.1000294\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinology and Metabolic Syndrome","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2161-1017.1000294","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Features of Lipid Metabolism and Level of Pro-inflammatory Cytokines in Patients with Type-2 Diabetes and with Diabetic Nephropathy Depending on the Stage of Chronic Kidney Disease
Purpose: Study of the role and relationship of lipid metabolism parameters and level of pro-inflammatory cytokines in patients with type-2 diabetes with diabetic nephropathy (DN) depending on the stage of chronic kidney disease (CKD). Materials and methods: 240 patients with type-2 diabetes were examined in the early stages of DN and CKD. Results: The development of DN was accompanied by an increase in the level of pro-inflammatory cytokines and impaired lipid metabolism (hypertriglyceridemia) in patients with type 2 diabetes. A negative correlation was found between the level of triglycerides (TG) and the glomerular filtration rate (GFR) (r=-0.43) and a direct relationship between the level of IL-6 and TG (r=0.48). Findings: An increase in the level of pro-inflammatory cytokines and TG increases the risk of the development and progression of DN and CKD.
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