{"title":"CA- 125在早期子宫内膜样癌中的预测作用","authors":"Begum Kurt, İ. Küçükyıldız, A. Yanik","doi":"10.7197/cmj.1299893","DOIUrl":null,"url":null,"abstract":"Objective: We aimed to evaluate the prognostic role of preoperative serum cancer antigen 125 (CA-125) in endometrioid endometrial cancer for determining the cut-off values for clinicopathological factors. \nStudy design: 161 patients were included in the study. The inclusion criteria were histopathological confirmation of endometrioid endometrial cancer and patients with CA-125 levels measured at most ten days before surgery. The association between CA-125 value and clinicopathological variables were analyzed. Receiver operating characteristic curve statistical tests with clinicopathological factors were used to determine the cut-off values and the prognostic role of CA-125. \nResults: The median value of CA-125 level was 15.4 (3, 2-577) IU/L. These CA-125 cut-off values ranged from 14.30 to 18.67 IU/L (sensitivity 53%– 100%, specificity 30%–59%). The statistical analysis showed a significant relation between CA-125 value and stage and pelvic-paraaortic lymph nodes metastasis. The average life expectancy of patients with CA-125 ≥15.4 was 102.8±5.9 months, whereas that of patients with CA-125","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"26 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The predictive role of CA- 125 value in early stage endometrioid endometrial cancer\",\"authors\":\"Begum Kurt, İ. Küçükyıldız, A. Yanik\",\"doi\":\"10.7197/cmj.1299893\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: We aimed to evaluate the prognostic role of preoperative serum cancer antigen 125 (CA-125) in endometrioid endometrial cancer for determining the cut-off values for clinicopathological factors. \\nStudy design: 161 patients were included in the study. The inclusion criteria were histopathological confirmation of endometrioid endometrial cancer and patients with CA-125 levels measured at most ten days before surgery. The association between CA-125 value and clinicopathological variables were analyzed. Receiver operating characteristic curve statistical tests with clinicopathological factors were used to determine the cut-off values and the prognostic role of CA-125. \\nResults: The median value of CA-125 level was 15.4 (3, 2-577) IU/L. These CA-125 cut-off values ranged from 14.30 to 18.67 IU/L (sensitivity 53%– 100%, specificity 30%–59%). The statistical analysis showed a significant relation between CA-125 value and stage and pelvic-paraaortic lymph nodes metastasis. The average life expectancy of patients with CA-125 ≥15.4 was 102.8±5.9 months, whereas that of patients with CA-125\",\"PeriodicalId\":10750,\"journal\":{\"name\":\"Cumhuriyet medical journal\",\"volume\":\"26 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cumhuriyet medical journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7197/cmj.1299893\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cumhuriyet medical journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7197/cmj.1299893","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The predictive role of CA- 125 value in early stage endometrioid endometrial cancer
Objective: We aimed to evaluate the prognostic role of preoperative serum cancer antigen 125 (CA-125) in endometrioid endometrial cancer for determining the cut-off values for clinicopathological factors.
Study design: 161 patients were included in the study. The inclusion criteria were histopathological confirmation of endometrioid endometrial cancer and patients with CA-125 levels measured at most ten days before surgery. The association between CA-125 value and clinicopathological variables were analyzed. Receiver operating characteristic curve statistical tests with clinicopathological factors were used to determine the cut-off values and the prognostic role of CA-125.
Results: The median value of CA-125 level was 15.4 (3, 2-577) IU/L. These CA-125 cut-off values ranged from 14.30 to 18.67 IU/L (sensitivity 53%– 100%, specificity 30%–59%). The statistical analysis showed a significant relation between CA-125 value and stage and pelvic-paraaortic lymph nodes metastasis. The average life expectancy of patients with CA-125 ≥15.4 was 102.8±5.9 months, whereas that of patients with CA-125
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