{"title":"尿中尿酸的希夫试验机制","authors":"F. Sánchez-Viesca, Reina Gómez","doi":"10.34198/ejcs.10123.4348","DOIUrl":null,"url":null,"abstract":"Uric acid in urine can be detected by reaction with silver nitrate in alkaline medium. A redox reaction occurs and black elemental silver is observed in the filter paper used in this test. However, the mechanism of the series of steps occurring in the uric acid molecule, including a second redox reaction, has not been advanced. A reaction route is provided, each step is fully commented giving also the electron flow. The mechanism involves free radicals and ionic intermediates as well. There is ring contraction with concomitant oxo-aziridine formation, imide hydrolysis, imine hydration to carbinol-amine, isomerization to ketone with concurrently ring opening, and assisted decarboxylation.","PeriodicalId":11449,"journal":{"name":"Earthline Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Mechanism of Schiff Test for Uric Acid in Urine\",\"authors\":\"F. Sánchez-Viesca, Reina Gómez\",\"doi\":\"10.34198/ejcs.10123.4348\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Uric acid in urine can be detected by reaction with silver nitrate in alkaline medium. A redox reaction occurs and black elemental silver is observed in the filter paper used in this test. However, the mechanism of the series of steps occurring in the uric acid molecule, including a second redox reaction, has not been advanced. A reaction route is provided, each step is fully commented giving also the electron flow. The mechanism involves free radicals and ionic intermediates as well. There is ring contraction with concomitant oxo-aziridine formation, imide hydrolysis, imine hydration to carbinol-amine, isomerization to ketone with concurrently ring opening, and assisted decarboxylation.\",\"PeriodicalId\":11449,\"journal\":{\"name\":\"Earthline Journal of Chemical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-02-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Earthline Journal of Chemical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34198/ejcs.10123.4348\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Earthline Journal of Chemical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34198/ejcs.10123.4348","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Mechanism of Schiff Test for Uric Acid in Urine
Uric acid in urine can be detected by reaction with silver nitrate in alkaline medium. A redox reaction occurs and black elemental silver is observed in the filter paper used in this test. However, the mechanism of the series of steps occurring in the uric acid molecule, including a second redox reaction, has not been advanced. A reaction route is provided, each step is fully commented giving also the electron flow. The mechanism involves free radicals and ionic intermediates as well. There is ring contraction with concomitant oxo-aziridine formation, imide hydrolysis, imine hydration to carbinol-amine, isomerization to ketone with concurrently ring opening, and assisted decarboxylation.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
