早期乳腺癌术中放射治疗论文立项并文献复习

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引用次数: 0

摘要

乳腺癌(BC)是一种具有重大社会意义的疾病。放射治疗(RT)是保乳手术(BPS)后早期BC复杂治疗的重要组成部分。部分乳房照射(PBI)已被确定为适当选择的早期乳腺癌妇女的合适治疗选择,可追溯到20世纪90年代的大量临床试验。肿瘤切除术中单剂量靶向放疗(TARGIT - IORT)是早期BC的一种PBI方法。在这篇文献综述中,我们将介绍术中放疗(IORT)对早期BC的治疗能力,必要患者的选择,以及与手术放疗相结合的优缺点。IORT具有潜在的疗效优势,涉及与降低心肺辐射剂量相关的总生存率,以及在肿瘤重建之前提高辅助辐射传递的准确性,或在高风险患者中用作促进以改善肿瘤控制。本研究项目的预期贡献是:1)在保加利亚首次将IORT用于早期乳腺癌的治疗;2)与有或没有增强的全乳照射相比,接受IORT患者的局部控制和早期毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intraoperative radiotherapy for early breast carcinoma-dissertation project with literary review
Breast cancer (BC) is a socially significant illness. Radiotherapy (RT) is an important part of the complex treatment of early BC after a breast preserving surgery (BPS). Partial breast irradiation (PBI) has been established as a suitable treatment option for appropriately selected women with early stage BC by numerous clinical trials dating back to the 1990s. Risk¬ adapted single¬ dose targeted intraoperative radiotherapy during lumpectomy (TARGIT ¬IORT) is a method of PBI for early BC. In this literary review, we will present the therapeutic capabilities of intraoperative radiotherapy (IORT) for early BC, the necessary patients’ selection, as well as the advantages and disadvantages of this combined with surgery radiotherapeutic approach. IORT has potential efficacy advantages related to overall survival related to reduced cardiopulmonary radiation doses, as well as prior to oncoplastic reconstruction to improve accuracy of adjuvant radiation delivery, or when used as a boost in higher risk patients to improve tumor control. The expected contributions from this research project are: 1) For the first time in Bulgaria to use IORT in the treatment of early breast cancer.;2) Local control and early toxicity for patients receiving IORT in comparison with whole breast irradiation with or without boost.
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