{"title":"阿达木单抗在实现临床和内镜下长期深度缓解方面是有效的:一个病例报告","authors":"Gionata Fiorino , Alessandro Repici , Alberto Malesci , Silvio Danese","doi":"10.1016/S1594-5804(11)60009-0","DOIUrl":null,"url":null,"abstract":"<div><p>Anti-tumour necrosis factor-alpha has dramatically changed the natural history of Crohn's disease in the last decades. Adalimumab is effective in inducing and maintaining clinical remission as well as in inducing deep mucosal healing, which is a prognostic factor for further progression of the disease. Long-term treatment with adalimumab is considered safe and should be continued for at least 3 years in patients with aggressive long-standing Crohn's disease.</p><p>We report the case of a 61-year-old woman with aggressive and complicated steroid-dependant Crohn's disease in whom clinical and endoscopic long-term deep remission was achieved for up to 3 years, without any need for steroids, hospitalization or surgery.</p></div>","PeriodicalId":100375,"journal":{"name":"Digestive and Liver Disease Supplements","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1594-5804(11)60009-0","citationCount":"0","resultStr":"{\"title\":\"Adalimumab is effective in achieving clinical and endoscopic long-term deep remission: A case report\",\"authors\":\"Gionata Fiorino , Alessandro Repici , Alberto Malesci , Silvio Danese\",\"doi\":\"10.1016/S1594-5804(11)60009-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Anti-tumour necrosis factor-alpha has dramatically changed the natural history of Crohn's disease in the last decades. Adalimumab is effective in inducing and maintaining clinical remission as well as in inducing deep mucosal healing, which is a prognostic factor for further progression of the disease. Long-term treatment with adalimumab is considered safe and should be continued for at least 3 years in patients with aggressive long-standing Crohn's disease.</p><p>We report the case of a 61-year-old woman with aggressive and complicated steroid-dependant Crohn's disease in whom clinical and endoscopic long-term deep remission was achieved for up to 3 years, without any need for steroids, hospitalization or surgery.</p></div>\",\"PeriodicalId\":100375,\"journal\":{\"name\":\"Digestive and Liver Disease Supplements\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1594-5804(11)60009-0\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Digestive and Liver Disease Supplements\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1594580411600090\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive and Liver Disease Supplements","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1594580411600090","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Adalimumab is effective in achieving clinical and endoscopic long-term deep remission: A case report
Anti-tumour necrosis factor-alpha has dramatically changed the natural history of Crohn's disease in the last decades. Adalimumab is effective in inducing and maintaining clinical remission as well as in inducing deep mucosal healing, which is a prognostic factor for further progression of the disease. Long-term treatment with adalimumab is considered safe and should be continued for at least 3 years in patients with aggressive long-standing Crohn's disease.
We report the case of a 61-year-old woman with aggressive and complicated steroid-dependant Crohn's disease in whom clinical and endoscopic long-term deep remission was achieved for up to 3 years, without any need for steroids, hospitalization or surgery.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
