抑制素及相关蛋白的鉴定和纯化。

Knight Pg
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引用次数: 21

摘要

在过去的5年里,“抑制素”的存在已经得到了确凿的证明。经过几十年对这种假定的性腺负反馈的非甾体介质的不确定性,抑制素已被纯化到均匀性,其物理化学和生物学特性被定义,编码其亚基的基因被克隆和测序,其生理作用被详细检查。最近,Burger(1988)提出了一个有用的工作定义:“抑制素是一种糖蛋白激素,由两种不同的二硫化物连接亚基组成,称为A和13,可抑制垂体促性腺激素的产生和/或分泌,特别是抑制促性腺激素的分泌。”在过去的几年里,有关抑制素的发现、分离和表征的文献已经被广泛地回顾了,读者可以在Findlay(1986)、de Jong(1987、1988)、Ying(1988)和Lincoln等人(1989)的综合综述中找到更多的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification and purification of inhibin and inhibin-related proteins.
Within the past 5 years the existence of 'inhibin' has been proven conclusively. After many decades of uncertainty surrounding this putative non-steroidal mediator of gonadal negative feedback, inhibin has been purified to homogeneity, its physico-chemical and biological properties defined, the genes encoding its subunits cloned and sequenced and its physiological role(s) examined in detail. A useful working definition recently proposed by Burger (1988) states that "inhibin is a glycoprotein hormone consisting of two dissimilar disulphide-linked subunits termed aand 13which inhibits pituitary gonadotrophin production and/or secretion, preferentially that of FSH". The literature relating to the discovery, isolation and characterization of inhibin has been reviewed extensively in the past few years and the reader will find much additional information in comprehensive reviews by Findlay (1986), de Jong (1987, 1988), Ying (1988) and Lincoln et al. (1989).
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