砷脂肪酸（As-FA 362）和砷烃（As-HC 444）的改进合成。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Synthesis-Stuttgart Pub Date : 2023-12-01 Epub Date: 2023-08-17 DOI:10.1055/a-2122-4287

Miguel A Chacon-Teran, Shubhra Bhattacharjee, Jeremy D Bailoo, Amrika Deonarine, Michael Findlater

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引用次数: 0

摘要

为制备一种砷脂肪酸（As-FA362）和一种砷碳氢化合物（As-HC444），我们开发了稳健可靠的合成方法。此外，还公开了获取新合成路线所需起始材料的改进路线。有了这些改进，预计含砷化合物的获取途径将会增加，这些化合物可用作开发生物基质中定量方法所需的标准。本文首次报告了这些化合物的稳定性数据。有了这些结果，我们计划就这些有机砷化物的消除概况、生物累积潜力以及病理行为和生理后果提供数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Improved Syntheses of an Arseno-Fatty Acid (As-FA 362) and an Arseno-Hydrocarbon (As-HC 444).

Robust and reliable synthetic methods have been developed for the preparation of an arseno-fatty acid (As-FA362) and an arseno-hydrocarbon (As-HC444). An improved route to access the starting materials necessary for the new synthetic routes is also disclosed. With these improvements, an increased accessibility to arsenic-containing compounds is anticipated, which may be deployed as standards required for the development of quantitative methods in biological matrices. For the first time, stability data for these compounds are reported. With these results in hand, data on the elimination profile, bioaccumulation potential and patho-behavioral and physiological consequences of these organoarsenicals are planned.

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来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.