微芯片对细胞悬浮液电性能的仿真与实验分析

2006 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems Pub Date : 2006-01-01 DOI:10.1109/NEMS.2006.334701

Mingfei Xiao, Zhaoying Zhou, Xing Yang, Yingfei Wu, Shangfeng Liu

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引用次数: 1

摘要

生物电阻抗谱(EIS)所获得的物理量可以反映生物丰富的电特性。介绍了一种可用于电阻抗谱分析的微晶片及其测量系统。一种新的环境影响评估方法正在兴起。根据初步的实验结果，可以对不同生理状态的海拉细胞悬浮液进行测量和区分。采用6元等效电路模型对实验结果进行了模拟。该微芯片具有分辨率高、操作方便等优点。它在细胞电生理、药物筛选和生物传感器等领域具有广阔的应用前景

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Simulation and Experiment Analysis for Electrical Property of Cell Suspension by Micro Chip

The physical quantity which is acquired from biological electrical impedance spectroscopy (EIS) can reflect the plentiful biological electrical characteristics. A microfabricated chip and related measurement system, which could be used for electrical impedance spectroscopy analysis, were introduced in this paper. A novel EIS measurement method is emerging. Based on the preliminary experimental results, the HeLa cell suspensions with different physiological status could be measured and distinguished. A 6-elements equivalent circuit model was used to simulate the experimental results. The micro chip has some advantages, such as high resolution and ease of operation. It shows application potentials in the fields of cellular electrophysiology, drug screening and bio-sensors, etc

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2006 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems

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