Effects of sevoflurame combined anesthsia on kidney function in pediatric living donor liver transplantation

Objective To evaluate the effect of propofol and sevoflurane on acute kidney function in infants undergoing pediatric parent liver transplantation. Methods 80 pediatric patients scheduled for pediatric liver transplantation were randomly assigned to receive either continuous infusion of propofol or inhalation of sevoflurane. Serum creatinine (Scr), inflammatory medium and renal biomarkers were measured before surgery (T1), 30min after anhepatic phase (T2), 3h after ischemia reperfusion (T3), 36 h after surgery(T4) to evaluate the effect of anesthetics on the development of postoperative kidney injury. Results Overall, compared Propofol group, the mean arterial pressure changed slightly in sevoflurane group. The inflammatory factors of Scr, IL-18, TNF-α, and levels of NGAL were lower in sevoflurane group while no differences of IL-10 were found between both groups. Conclusions Compared with propofol anesthesia, the degree of renal injury in pediatric living donor liver transplantion under sevoflurane anesthesia is reduced, which may be related to hemodynamic stability and decreased release of inflammatory factors. Key words: Pediatric liver transplantation; Sevoflurane; Acute kidney injury