{"title":"6-氨基青霉素酸衍生物。α-Amino-p-hydroxy-benzylpenicillin","authors":"A. Long, J. Nayler, H. Smith, T. Taylor, N. Ward","doi":"10.1039/J39710001920","DOIUrl":null,"url":null,"abstract":"α-Amino-p-hydroxyphenylacetic acid was resolved and the isomeric amino-acids were coupled with 6-aminopenicillanic acid by two methods to give both epimers of α-amino-p-hydroxybenzylpenicillin. The epimer derived from (–)-D-α-amino-p-hydroxyphenylacetic acid has a broad spectrum of antibacterial activity and is exceptionally well absorbed into the bloodstream after administration by mouth.","PeriodicalId":17245,"journal":{"name":"Journal of The Chemical Society C: Organic","volume":"44 1","pages":"1920-1922"},"PeriodicalIF":0.0000,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":"{\"title\":\"Derivatives of 6-aminopenicillanic acid. Part XI. α-Amino-p-hydroxy-benzylpenicillin\",\"authors\":\"A. Long, J. Nayler, H. Smith, T. Taylor, N. Ward\",\"doi\":\"10.1039/J39710001920\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"α-Amino-p-hydroxyphenylacetic acid was resolved and the isomeric amino-acids were coupled with 6-aminopenicillanic acid by two methods to give both epimers of α-amino-p-hydroxybenzylpenicillin. The epimer derived from (–)-D-α-amino-p-hydroxyphenylacetic acid has a broad spectrum of antibacterial activity and is exceptionally well absorbed into the bloodstream after administration by mouth.\",\"PeriodicalId\":17245,\"journal\":{\"name\":\"Journal of The Chemical Society C: Organic\",\"volume\":\"44 1\",\"pages\":\"1920-1922\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1971-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The Chemical Society C: Organic\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/J39710001920\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Chemical Society C: Organic","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/J39710001920","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
摘要
将α-氨基-对羟基苯基乙酸拆分，用两种方法将氨基酸同分异构体与6-氨基青霉素酸偶联，得到α-氨基-对羟基苯青霉素的两个外显体。从(-)- d -α-氨基-对羟基苯基乙酸中提取的外显体具有广谱的抗菌活性，并且在口服给药后特别容易被血液吸收。
Derivatives of 6-aminopenicillanic acid. Part XI. α-Amino-p-hydroxy-benzylpenicillin
α-Amino-p-hydroxyphenylacetic acid was resolved and the isomeric amino-acids were coupled with 6-aminopenicillanic acid by two methods to give both epimers of α-amino-p-hydroxybenzylpenicillin. The epimer derived from (–)-D-α-amino-p-hydroxyphenylacetic acid has a broad spectrum of antibacterial activity and is exceptionally well absorbed into the bloodstream after administration by mouth.
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