血浆置换影响外周血淋巴细胞辅助T -1型/辅助T -2型平衡。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2001-12-01 DOI:10.1046/J.1526-0968.2001.00386.X

H. Goto, H. Matsuo, S. Nakane, H. Izumoto, T. Fukudome, C. Kambara, N. Shibuya

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引用次数: 59

摘要

血浆置换不仅可以去除体液因子，还可以调节细胞免疫。我们研究了血浆置换是否影响3例神经免疫性疾病患者的辅助性T -1型/辅助性T -2型(Th1/Th2)细胞因子生成-细胞平衡。检测抗cd3和抗cd28刺激外周血单个核细胞培养上清中干扰素- γ (ifn - γ)、白细胞介素-2 (IL-2)和IL-4的产生。在3例患者中，2例血浆置换(免疫吸附或血浆置换)降低了Th1/Th2细胞因子比率。结果提示血浆置换可引起外周血中Th1/Th2平衡的改变。

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Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes.

Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immunoadsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

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Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis

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