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Kartika Jurnal Ilmiah Farmasi Pub Date : 2019-09-30 DOI:10.20885/JIF.VOL15.ISS1.ART1

Haeria Doloking, Nurismi Dhuha, Pratiwi Ningsi

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引用次数: 0

摘要

背景本质:印度尼西亚制药原料生产实现自力更生的努力之一是利用这家工厂作为资源。迪奥斯科里亚·阿拉塔(Dioscorea alata L)是需要研究的潜在淀粉资源之一，作为消化药片的开发。目的:本研究的目的是了解地球淀粉的特性，并了解其合成药片的潜力。方法:特征分析包括proksimat、淀粉含量、颗粒状形态、晶体、发展力和水容量的结合。合成的潜在研究是通过用山梨酸淀粉与玉米淀粉进行配制来进行的。对衰减性质的评估是通过衰减试验、脆化试验、暴力测试和药片解药测试进行的。结果:根据对地淀粉特性的研究，水、灰烬、蛋白质和脂肪的含量分别为13.08%、0.23%、143%和0.81%。然后，淀粉样蛋白是18.08%。水肿和结节容量为1 21和3.31。颗粒状的形态分析显示了椭圆状和球体。淀粉晶体显示半晶体形式的ortorom魔方晶体模式。药片的合成试验表明，一级和二级方程式的衰减时间为3.50和4.25。I和II公式的可行性测试为0.011%和0.008%。一级和一级方程式显示5公斤和6公斤。I和II配方的测试显示88.85%和85.58%。结论:从结果来看，Dioscorea alata。我)凝视着平板电脑的分解材料抽象背景:一种努力去认识到印尼制药原料的原始材料生产是一种资源。Dioscorea alata，作为starch sources中的一员，需要像合成药片一样开发潜力。研究的结果是确定二叠纪烷的特性并找出潜在的人工合成材料。方法:Characteristic分析包括proximate、淀粉性分析、颗粒形态学、晶体学、膨胀力和水电学结合。合成后的潜在研究是由一种piroxicam药材制成的，这种药材使用的是迪奥斯科利亚阿拉塔(Dioscorea alata starch)与玉米田(corn starch)相比较。破坏财产的评估是通过合成测试、摩擦测试、困难测试和分解标签测试而表现出来的。建议:基于Dioscorea alata . starch, water, ash，蛋白质和fat contents为13.08%，0.23%，1.43%和0.81%的尊重研究。然后，淀粉量是18.08%。膨胀的电力和水相结合1.21和3.31。形态分析:星号的晶体以半晶体形式形式呈现，或多角晶体模式。合成试验试验I和II的结果是合成时间3.50和4.25。I -配方和公式II的危险测试是0.011%，0.008%。最难测试的公式I和公式II显示5公斤和6公斤。85% 85.58%结果:经过results, Dioscorea alata

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Studi potensi ubi kelapa (Dioscorea alata. L) sebagai bahan penghancur tablet

Intisari Latar Belakang: Salah satu upaya untuk mewujudkan kemandirian produksi bahan baku farmasi Indonesia adalah dengan memanfaatkan pabrik sebagai sumber. Dioscorea alata L sebagai salah satu sumber pati perlu dipelajari untuk pengembangan potensial sebagai tablet disintegran. Tujuan: Tujuan penelitian ini adalah untuk mengetahui karakteristik pati Dioscorea alata L. dan mengetahui potensi sebagai bahan disintegran tablet. Metode: Analisis karakteristik meliputi proksimat, kandungan amilosa, morfologi granular, kristalinitas, kekuatan pengembangan, dan pengikatan kapasitas air. Studi potensial sebagai disintegran dilakukan dengan merumuskan tablet piroksikam menggunakan pati Dioscorea alata dibandingkan dengan pati jagung. Evaluasi sifat-sifat disintegran dilakukan dengan uji disintegrasi, uji kerapuhan, uji kekerasan, dan uji disolusi tablet. Hasil: Berdasarkan studi karakteristik pati Dioscorea alata L., kadar air, abu, protein, dan lemak masing-masing adalah 13,08%, 0,23%, 1,43%, dan 0,81%. Kemudian, Amilosa adalah 18,08%. Daya bengkak dan pengikatan kapasitas air menunjukkan 1,21 dan 3,31. Analisis morfologi granular menunjukkan bentuk ellipsoid dan bola. Kristal pati menunjukkan bentuk semikristal dengan pola kristal ortorombik. Uji disintegrasi tablet menunjukkan bahwa formula I dan II, memiliki waktu hancur 3,50 dan 4,25. Uji kelayakan formula I dan formula II adalah 0,011% dan 0,008%. Uji kekerasan Formula I dan Formula II menunjukkan 5kg dan 6kg. Uji disolusi Formula I dan Formula II menunjukkan 88,85% dan 85,58%. Kesimpulan: Dari hasil tersebut, pati Dioscorea alata L. berpotensi sebagai bahan penghancur tablet Kata kunci: Dioscorea alata L., tablet, disintegrant, pati, bahan baku Potential Study of Ubi Kelapa (Dioscorea Alata. L) Starch as Tablet Desintegrant Material Abstract Background: One of the efforts to realize the sovereignty of Indonesia's pharmaceutical raw material production is to utilize the plant as a source. Dioscorea alata L as one of the starch sources needs to be studied for potential development as a tablet disintegrant. Objective: The aims of the research are to determine the characteristic of Dioscorea alata L. starch and to find out the potential as tablet disintegrant material. Method: Characteristic analysis include are proximate, amylose content, granular morphology, crystallinity, swelling power, and water capacity binding. The potential study as disintegrant was performed by formulating a piroxicam tablet using Dioscorea alata starch compared to corn starch. Evaluation of the disintegrant properties was performed by disintegration test, friability test, hardness test, and dissolution test of the tablets. Results: Based on the characteristic study of Dioscorea alata L. starch, water, ash, protein, and fat contents are 13.08%, 0.23%, 1.43%, and 0.81%, respectively. Then, Amylose is 18.08%. Swelling power and water capacity binding shows 1.21 and 3.31. Glanular morphology analysis shows ellipsoid and spherical form. The crystallinity of the starch shows as semicrystal form with orthorhombic crystal pattern. Tablet disintegration test shows that formula I and II, has disintegration time 3.50 and 4.25. Friability test of formula I and formula II is 0.011% and 0.008%. Hardness test of Formula I and Formula II shows 5kg and 6kg. Dissolution test of Formula I and formula II shows 88.85% and 85.58%. Conclusion: Over the results, the Dioscorea alata L. starch has the potential as the tablet disintegrant material Keywords: Dioscorea alata L., tablet, disintegrant, starch, raw material

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Kartika Jurnal Ilmiah Farmasi

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16 weeks