Elke Kaemmerer, Tayner E. Rodriguez Garzon, Aaron M. Lock, Carrie J. Lovitt, Vicky M. Avery
{"title":"创新乳腺癌药物发现的体外模型","authors":"Elke Kaemmerer, Tayner E. Rodriguez Garzon, Aaron M. Lock, Carrie J. Lovitt, Vicky M. Avery","doi":"10.1016/j.ddmod.2017.02.002","DOIUrl":null,"url":null,"abstract":"<div><p>Breast cancer is a complex group of diseases and is one of the most common cancers diagnosed worldwide. Many studies have shown that tumour progression and drug responses vary due to tumour heterogeneity caused by genetic mutations<span><span> and aberrant protein expression<span> and are also directly affected by the local tumour microenvironment. To identify new targets, and/or evaluate potential new chemotherapeutics, with the ultimate goal of improving success rates and thus available treatment options, in vitro cell culture systems incorporating global tumour complexity are needed. This review provides an overview of the recent developments with respect to in vitro 2D, 3D and microfluidics </span></span>cell culture techniques which mimic tumourigenesis, thus providing advanced model systems able to predict clinical drug responses.</span></p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"21 ","pages":"Pages 11-16"},"PeriodicalIF":0.0000,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2017.02.002","citationCount":"3","resultStr":"{\"title\":\"Innovative in vitro models for breast cancer drug discovery\",\"authors\":\"Elke Kaemmerer, Tayner E. Rodriguez Garzon, Aaron M. Lock, Carrie J. Lovitt, Vicky M. Avery\",\"doi\":\"10.1016/j.ddmod.2017.02.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Breast cancer is a complex group of diseases and is one of the most common cancers diagnosed worldwide. Many studies have shown that tumour progression and drug responses vary due to tumour heterogeneity caused by genetic mutations<span><span> and aberrant protein expression<span> and are also directly affected by the local tumour microenvironment. To identify new targets, and/or evaluate potential new chemotherapeutics, with the ultimate goal of improving success rates and thus available treatment options, in vitro cell culture systems incorporating global tumour complexity are needed. This review provides an overview of the recent developments with respect to in vitro 2D, 3D and microfluidics </span></span>cell culture techniques which mimic tumourigenesis, thus providing advanced model systems able to predict clinical drug responses.</span></p></div>\",\"PeriodicalId\":39774,\"journal\":{\"name\":\"Drug Discovery Today: Disease Models\",\"volume\":\"21 \",\"pages\":\"Pages 11-16\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ddmod.2017.02.002\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Discovery Today: Disease Models\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1740675716300160\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: Disease Models","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740675716300160","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Innovative in vitro models for breast cancer drug discovery
Breast cancer is a complex group of diseases and is one of the most common cancers diagnosed worldwide. Many studies have shown that tumour progression and drug responses vary due to tumour heterogeneity caused by genetic mutations and aberrant protein expression and are also directly affected by the local tumour microenvironment. To identify new targets, and/or evaluate potential new chemotherapeutics, with the ultimate goal of improving success rates and thus available treatment options, in vitro cell culture systems incorporating global tumour complexity are needed. This review provides an overview of the recent developments with respect to in vitro 2D, 3D and microfluidics cell culture techniques which mimic tumourigenesis, thus providing advanced model systems able to predict clinical drug responses.
期刊介绍:
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.