创新乳腺癌药物发现的体外模型

Q3 Pharmacology, Toxicology and Pharmaceutics
Elke Kaemmerer, Tayner E. Rodriguez Garzon, Aaron M. Lock, Carrie J. Lovitt, Vicky M. Avery
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引用次数: 3

摘要

乳腺癌是一组复杂的疾病,是世界上最常见的癌症之一。许多研究表明,由于基因突变和异常蛋白表达引起的肿瘤异质性,肿瘤的进展和药物反应也会有所不同,并直接受到局部肿瘤微环境的影响。为了确定新的靶点,和/或评估潜在的新化疗药物,以提高成功率和可用的治疗方案为最终目标,需要结合全球肿瘤复杂性的体外细胞培养系统。本文综述了模拟肿瘤发生的体外2D、3D和微流体细胞培养技术的最新进展,从而提供了能够预测临床药物反应的先进模型系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Innovative in vitro models for breast cancer drug discovery

Breast cancer is a complex group of diseases and is one of the most common cancers diagnosed worldwide. Many studies have shown that tumour progression and drug responses vary due to tumour heterogeneity caused by genetic mutations and aberrant protein expression and are also directly affected by the local tumour microenvironment. To identify new targets, and/or evaluate potential new chemotherapeutics, with the ultimate goal of improving success rates and thus available treatment options, in vitro cell culture systems incorporating global tumour complexity are needed. This review provides an overview of the recent developments with respect to in vitro 2D, 3D and microfluidics cell culture techniques which mimic tumourigenesis, thus providing advanced model systems able to predict clinical drug responses.

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来源期刊
Drug Discovery Today: Disease Models
Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery
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期刊介绍: Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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