卡介苗- Guerin免疫疗法显著延长前列腺癌动物的生存期

D. Lamm, D. Riggs, David A. Donley, Justin White, R. Yeater, R. Bryner
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引用次数: 0

摘要

目的:卡介苗(Bacillus calmetet - guerin, BCG)是膀胱原位癌的首选治疗方法,但在其他肿瘤中的应用非常有限。本研究评估局灶内BCG在PA3大鼠前列腺癌模型中的作用。材料与方法:将105只大鼠随机分为4组。实验第0天,每组皮下注射1 × 106个PA3细胞。在实验第7天,各组接受每周6次治疗中的第一次。处理方法为生理盐水、BCG 1 × 104菌落形成单位(cfu)、BCG 1 × 105菌落形成单位、BCG 1 × 106菌落形成单位。在整个实验过程中监测所有动物的肿瘤生长情况。结果:接受BCG 1 × 106 cfu治疗的动物肿瘤体积减少幅度最大([mean±SD] 4130.0±1738.3 mm3;p = 0.0738),其次是卡介苗1 × 104 cfu(4527.6±1932.7 mm3;p = 0.1093)和BCG 1 × 105 cfu(4838.2±1889.9 mm3;P = 0.5218),而生理盐水对照组(5445.0±3119.5 mm3)。接种BCG 1 × 106 cfu组动物移植后第60天存活率显著提高(26只动物中19只[73.1%];P = 0.0326),与接受生理盐水溶液对照组(27只动物中的12只[44%])相比。卡介苗1 × 105 cfu治疗(26只存活11只[42.3%];p = 0.5479)和卡介苗1 × 104 cfu(26只存活13只[50%];P = 0.4484)与生理盐水对照组相比,也降低了生存率,但没有显著性水平。结论:病灶内接种卡介苗的动物肿瘤生长和动物死亡率持续降低,表明在这种侵袭性前列腺癌模型中具有抗肿瘤活性。最高剂量的卡介苗效果最好,这表明在该模型中较高的剂量可能是最佳的。卡介苗免疫治疗前列腺癌值得临床评价。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bacillus Calmette‐Guerin Immunotherapy Significantly Prolongs Survival of Animals with Prostate Cancer
Objectives: Bacillus Calmette-Guerin (BCG) is the treatment of choice for carcinoma in situ of the bladder, but its application to other cancers is very limited. The current study evaluates the effect of intralesional BCG in the PA3 rat prostate cancer model. Materials and Methods: One hundred five rats were randomized to four groups. Each group received 1 × 106 PA3 cells subcutaneously on experiment Day 0. On experimental Day 7, the groups received the first of six weekly treatments. Treatments consisted of saline solution, BCG 1 × 104 colony-forming units (cfu), BCG 1 × 105 cfu, and BCG 1 × 106 cfu. All animals were monitored for tumor growth throughout the duration of the experiment. Results: Animals receiving treatments with BCG 1 × 106 cfu exhibited the greatest reduction in tumor volume ([mean ± SD] 4130.0 ± 1738.3 mm3; p = 0.0738), followed by those receiving BCG 1 × 104 cfu (4527.6 ± 1932.7 mm3; p = 0.1093) and BCG 1 × 105 cfu (4838.2 ± 1889.9 mm3; p = 0.5218), compared to those receiving the saline solution control (5445.0 ± 3119.5 mm3). Animal survival on Day 60 after transplantation was significantly increased in the group receiving BCG 1 × 106 cfu (19 [73.1%] of 26 animals; p = 0.0326) when compared to those receiving the saline solution control (12 [44%] of 27 animals). Treatment with BCG 1 × 105 cfu (11 [42.3%] of 26 animals survived; p = 0.5479) and BCG 1 × 104 cfu (13 [50%] of 26 animals survived; p = 0.4484) also reduced survival compared to the saline solution control, but not to the level of significance. Conclusions: The consistent reduction in tumor growth and animal mortality in animals receiving intralesional BCG demonstrates antitumor activity in this aggressive model of prostate cancer. The greatest efficacy was seen with the highest dose of BCG, suggesting that higher doses may be optimal in this model. BCG immunotherapy of prostate cancer warrants clinical evaluation.
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