用持续注意测量法研究轻度低温对认知的影响

E. Lacey, R. O’Connell, S. O’Mara, P. Dockree
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引用次数: 1

摘要

轻度诱导低温治疗已经被认为是一种成功的方法,可以为缺血性中风、心脏骤停和创伤性脑损伤(TBI)患者提供神经保护治疗。抗炎反应和脑代谢率的降低,导致神经元凋亡的减少,被认为是这一过程对患者有益的主要机制。对一种可能被应急服务单位使用的新型水基冷却装置的评估,为目前的研究提供了动力。神经正常的参与者接受了两种处理:一种是冷却过程,将冷却头盔内的水循环温度维持在4°C;另一种是不冷却/假的过程,将温度设定在18°C。在治疗期间,参与者被要求执行一项基于计算机的任务,通过参与者在目标检测期间的反应时间来测量持续的注意力/警惕性。每组治疗前后均记录脑电图(EEG)。在整个过程中监测参与者的核心温度(通过鼓膜记录)。研究结果显示,在控制了参与者的身体质量指数(BMI)后,由于降温,气温下降了0.62°C,这在统计上是可靠的。然而,温度降低没有引起可靠的认知和脑电谱变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the Effects of Mild Induced Hypothermia on Cognition using a Measure of Sustained Attention
Mild Induced hypothermia has come to be recognised as a successful method of providing neuro-protective treatment for patients suffering ischemic stroke, cardiac arrest and traumatic brain injury (TBI). Anti-inflammatory responses and the lowering of cerebral metabolic rates, leading to a reduction in neuronal apoptosis, are considered to be the main mechanisms by which this process benefits patients. Assessment of a new hydro based cooling device, which could potentially be used by emergency service units, provided the impetus for the current research. Neurologically normal participants underwent two treatments: a cooling procedure where the temperature of water circulating in a cooling helmet was maintained at 4∘C and a non-cooling/sham procedure where the temperature was set at 18∘C. During treatment participants were required to perform a computer-based task that measured sustained attention/vigilance via participant response times during target detection. Electroencephalographic (EEG) recordings were also acquired before and after each treatment condition. Participants' core temperature (recorded via tympanic membrane) was monitored throughout the process. The findings revealed a statistically reliable 0.62 ∘C decrease in temperature as a result of cooling after controlling for participants' body mass index (BMI). However, there were no reliable cognitive or EEG spectral changes induced by the decrease in temperature.
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